arXiv:2604.01452v1 Announce Type: new Abstract: Scientific discovery is slowed by fragmented literature that requires excessive human effort to gather, analyze, and understand. AI tools, including autonomous summarization and question answering, have been developed to aid in understanding scientific literature. However, these tools lack the structured, multi-step approach necessary for extracting deep insights from scientific literature. Large Language Models (LLMs) offer new possibilities for literature analysis, but remain unreliable due to hallucinations and incomplete extraction. We introduce Elhuyar, a multi-agent, human-in-the-loop system that integrates LLMs, structured AI, and human scientists to extract, analyze, and iteratively refine insights from scientific literature. The framework distributes tasks among specialized agents for filtering papers, extracting data, fitting models, and summarizing findings, with human oversight ensuring reliability. The system generates structured reports with extracted data, visualizations, model equations, and text summaries, enabling deeper inquiry through iterative refinement. Deployed in materials science, it analyzed literature on tungsten under helium-ion irradiation, showing experimentally correlated exponential helium bubble growth with irradiation dose and temperature, offering insight for plasma-facing materials (PFMs) in fusion reactors. This demonstrates how AI-assisted literature review can uncover scientific patterns and accelerate discovery.

arXiv:2604.01461v1 Announce Type: new Abstract: Reducing hallucinations in Large Language Models (LLMs) is essential for improving the accuracy of data extraction from large text corpora. Current methods, like prompt engineering and chain-of-thought prompting, focus on individual documents but fail to consider relationships across a corpus. This paper introduces Peer Context Outlier Detection (P-COD), a novel approach that uses the relationships between documents to improve extraction accuracy. Our application domain is in scientific literature summarization, where papers with similar experiment settings should draw similar conclusions. By comparing extracted data to validated peer information within the corpus, we adjust confidence scores and flag low-confidence results for expert review. High-confidence results, supported by peer validation, are considered reliable. Our experiments demonstrate up to 98% precision in outlier detection across 6 domains of science, demonstrating that our design reduces hallucinations, enhances trust in automated systems, and allows researchers to focus on ambiguous cases, streamlining the data extraction workflows.

arXiv:2604.02259v1 Announce Type: cross Abstract: To harness the power of Language Models in answering domain specific specialized technical questions, Retrieval Augmented Generation (RAG) is been used widely. In this work, we have developed a Q\&A application inspired by the Retrieval Augmented Generation (RAG), which is comprised of an in-house database indexed on the arXiv articles related to the Electron-Ion Collider (EIC) experiment - one of the largest international scientific collaboration and incorporated an open-source LLaMA model for answer generation. This is an extension to it's proceeding application built on proprietary model and Cloud-hosted external knowledge-base for the EIC experiment. This locally-deployed RAG-system offers a cost-effective, resource-constraint alternative solution to build a RAG-assisted Q\&A application on answering domain-specific queries in the field of experimental nuclear physics. This set-up facilitates data-privacy, avoids sending any pre-publication scientific data and information to public domain. Future improvement will expand the knowledge base to encompass heterogeneous EIC-related publications and reports and upgrade the application pipeline orchestration to the LangGraph framework.

arXiv:2510.13714v3 Announce Type: replace-cross Abstract: Video comprises the vast majority of bits that are generated daily, and is the primary signal driving current innovations in robotics, remote sensing, and wearable technology. Yet, the most powerful video understanding models are too expensive for the resource-constrained platforms used in these applications. One approach is to offload inference to the cloud; this gives access to GPUs capable of processing high-resolution videos in real time. But even with reliable, high-bandwidth communication channels, the combined latency of video encoding, model inference, and round-trip communication prohibits use for certain real-time applications. The alternative is to use fully local inference; but this places extreme constraints on computational and power costs, requiring smaller models and lower resolution, leading to degraded accuracy. To address these challenges, we propose Dedelayed, a real-time inference system that divides computation between a remote model operating on delayed video frames and a local model with access to the current frame. The remote model is trained to make predictions on anticipated future frames, which the local model incorporates into its prediction for the current frame. The local and remote models are jointly optimized with an autoencoder that limits the transmission bitrate required by the available downlink communication channel. We evaluate Dedelayed on the task of real-time streaming video segmentation using the BDD100k driving dataset. For a round trip delay of 100 ms, Dedelayed improves performance by 6.4 mIoU compared to fully local inference and 9.8 mIoU compared to remote inference -- an equivalent improvement to using a model ten times larger. We release our training code, pretrained models, and python library at https://github.com/InterDigitalInc/dedelayed .

arXiv:2603.26203v2 Announce Type: replace-cross Abstract: Technology change happens quickly such that new trends tend to crowd out the focus on what was new just yesterday. In this paper the peak popularity of the confluence of Object Technologies with early Web adoption is explored through the content of a seminar held in 1999. Distributed architectures were undergoing significant change at this point, and deeper software capabilities were just beginning to be broadly accessible over the Internet. The Object Web arose and was infused with new development tools reflecting these capabilities and allowing design of applications for deployment during the early days of the World Wide Web. This conference discussed the history, evolution, and use of these tools, architectures, and their future possibilities. The continued dominance of these approaches although under different names is demonstrated even though the term Object Web has receded in use. Favored newer offerings such as Kubernetes and microservices still model the core design attributes of the Object Web for example. Aside from connecting this seminar to relevance in the software world of today this paper also touches on the early AI tools demonstrated in this seminar a quarter century ago and how the popularity wave of any given technology might affect the current focus on AI technology offerings.

Nature Medicine, Published online: 03 April 2026; doi:10.1038/s41591-026-04305-w

To accelerate therapeutic development and equip stakeholders with clear benchmarks, the authors outline target product profiles for therapies designed to delay or prevent the onset of clinical symptoms of Alzheimer’s disease.

Nature Cancer, Published online: 03 April 2026; doi:10.1038/s43018-026-01142-1

Izar and colleagues review the insights into cancer biology gained via single-cell analyses and spatial profiling and overview the challenges and opportunities associated with the implementation of these approaches to guide clinical discovery.

Nature Medicine, Published online: 02 April 2026; doi:10.1038/s41591-026-04379-6

Author Correction: Real-world clinical utility of tumor whole-genome sequencing in solid cancers

Nature Medicine, Published online: 02 April 2026; doi:10.1038/s41591-026-04281-1

A prespecified analysis from the SELECT trial showed that semaglutide reduces major adverse cardiovascular events by 20% compared with placebo, particularly in patients at high risk of fibrosis, as indicated by the Fibrosis-4 index.

Nature, Published online: 02 April 2026; doi:10.1038/d41586-026-00809-0

Chemistry that forms an omnipresent type of carbon–carbon bond enables the modular synthesis of 3D organic molecules — a boon for drug discovery and materials design.

The E3-ome defines the human repertoire of ubiquitin E3 ligases, creating a unified resource that maps their diversity across the ubiquitin and ubiquitin-like systems. By consolidating fragmented knowledge, this framework provides a foundation for studying ubiquitin signaling and accelerating discovery.

Deep proteome profiling of over 5,000 cerebrospinal fluid samples by mass spectrometry maps protein alterations across major neurological disorders, resolving key sources of variation as well as shared and disease-specific signatures. This framework yields a 22-protein assay that improves the differential diagnosis of multiple sclerosis from other inflammatory conditions, particularly in diagnostically challenging oligoclonal band-negative individuals.