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Received — 8 April 2026 ⏭

Cardinality Estimation for High Dimensional Similarity Queries with Adaptive Bucket Probing

✇cs.AI, q-bio.NC updates on arXiv.org
By: Zhonghan Chen · Qintian Guo · Ruiyuan Zhang · Xiaofang Zhou
7 April 2026 at 12:00
arXiv:2604.04603v1 Announce Type: cross Abstract: In this work, we address the problem of cardinality estimation for similarity search in high-dimensional spaces. Our goal is to design a framework that is lightweight, easy to construct, and capable of providing accurate estimates with satisfying online efficiency. We leverage locality-sensitive hashing (LSH) to partition the vector space while preserving distance proximity. Building on this, we adopt the principles of classical multi-probe LSH to adaptively explore neighboring buckets, accounting for distance thresholds of varying magnitudes. To improve online efficiency, we employ progressive sampling to reduce the number of distance computations and utilize asymmetric distance computation in product quantization to accelerate distance calculations in high-dimensional spaces. In addition to handling static datasets, our framework includes updating algorithm designed to efficiently support large-scale dynamic scenarios of data updates.Experiments demonstrate that our methods can accurately estimate the cardinality of similarity queries, yielding satisfying efficiency.

Xpertbench: Expert Level Tasks with Rubrics-Based Evaluation

✇cs.AI, q-bio.NC updates on arXiv.org
By: Xue Liu · Xin Ma · Yuxin Ma · Yongchang Peng · Duo Wang · Zhoufutu Wen · Ge Zhang · Kaiyuan Zhang · Xinyu Chen · Tianci He · Jiani Hou · Liang Hu · Ziyun Huang · Yongzhe Hui · Jianpeng Jiao · Chennan Ju · Yingru Kong · Yiran Li · Mengyun Liu · Luyao Ma · Fei Ni · Yiqing Ni · Yueyan Qiu · Yanle Ren · Zilin Shi · Zaiyuan Wang · Wenjie Yue · Shiyu Zhang · Xinyi Zhang · Kaiwen Zhao · Zhenwei Zhu · Shanshan Wu · Qi Zhao · Wenhao Huang
7 April 2026 at 12:00
arXiv:2604.02368v3 Announce Type: replace Abstract: As Large Language Models (LLMs) exhibit plateauing performance on conventional benchmarks, a pivotal challenge persists: evaluating their proficiency in complex, open-ended tasks characterizing genuine expert-level cognition. Existing frameworks suffer from narrow domain coverage, reliance on generalist tasks, or self-evaluation biases. To bridge this gap, we present XpertBench, a high-fidelity benchmark engineered to assess LLMs across authentic professional domains. XpertBench consists of 1,346 meticulously curated tasks across 80 categories, spanning finance, healthcare, legal services, education, and dual-track research (STEM and Humanities). These tasks are derived from over 1,000 submissions by domain experts--including researchers from elite institutions and practitioners with extensive clinical or industrial experience--ensuring superior ecological validity. Each task uses detailed rubrics with mostly 15-40 weighted checkpoints to assess professional rigor. To facilitate scalable yet human-aligned assessment, we introduce ShotJudge, a novel evaluation paradigm that employs LLM judges calibrated with expert few-shot exemplars to mitigate self-rewarding biases. Our empirical evaluation of state-of-the-art LLMs reveals a pronounced performance ceiling: even leading models achieve a peak success rate of only ~66%, with a mean score around 55%. Models also exhibit domain-specific divergence, showing non-overlapping strengths in quantitative reasoning versus linguistic synthesis.. These findings underscore a significant "expert-gap" in current AI systems and establish XpertBench as a critical instrument for navigating the transition from general-purpose assistants to specialized professional collaborators.

Document Parsing Unveiled: Techniques, Challenges, and Prospects for Structured Information Extraction

✇cs.AI, q-bio.NC updates on arXiv.org
By: Qintong Zhang · Bin Wang · Victor Shea-Jay Huang · Junyuan Zhang · Zhengren Wang · Hao Liang · Conghui He · Wentao Zhang
7 April 2026 at 12:00
arXiv:2410.21169v5 Announce Type: replace-cross Abstract: Document parsing (DP) transforms unstructured or semi-structured documents into structured, machine-readable representations, enabling downstream applications such as knowledge base construction and retrieval-augmented generation (RAG). This survey provides a comprehensive and timely review of document parsing research. We propose a systematic taxonomy that organizes existing approaches into modular pipeline-based systems and unified models driven by Vision-Language Models (VLMs). We provide a detailed review of key components in pipeline systems, including layout analysis and the recognition of heterogeneous content such as text, tables, mathematical expressions, and visual elements, and then systematically track the evolution of specialized VLMs for document parsing. Additionally, we summarize widely adopted evaluation metrics and high-quality benchmarks that establish current standards for parsing quality. Finally, we discuss key open challenges, including robustness to complex layouts, reliability of VLM-based parsing, and inference efficiency, and outline directions for building more accurate and scalable document intelligence systems.

Security Considerations for Artificial Intelligence Agents

✇cs.AI, q-bio.NC updates on arXiv.org
By: Ninghui Li · Kaiyuan Zhang · Kyle Polley · Jerry Ma
7 April 2026 at 12:00
arXiv:2603.12230v2 Announce Type: replace-cross Abstract: This article, a lightly adapted version of Perplexity's response to NIST/CAISI Request for Information 2025-0035, details our observations and recommendations concerning the security of frontier AI agents. These insights are informed by Perplexity's experience operating general-purpose agentic systems used by millions of users and thousands of enterprises in both controlled and open-world environments. Agent architectures change core assumptions around code-data separation, authority boundaries, and execution predictability, creating new confidentiality, integrity, and availability failure modes. We map principal attack surfaces across tools, connectors, hosting boundaries, and multi-agent coordination, with particular emphasis on indirect prompt injection, confused-deputy behavior, and cascading failures in long-running workflows. We then assess current defenses as a layered stack: input-level and model-level mitigations, sandboxed execution, and deterministic policy enforcement for high-consequence actions. Finally, we identify standards and research gaps, including adaptive security benchmarks, policy models for delegation and privilege control, and guidance for secure multi-agent system design aligned with NIST risk management principles.

Decoding macrophage heterogeneity in the pulmonary fibrosis lung cancer transition

✇(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
By: Hanming Yu · Mengmeng Zhao · Qiuhong Li · Yuan Zhang
6 April 2026 at 18:00

Front Immunol. 2026 Mar 20;17:1787094. doi: 10.3389/fimmu.2026.1787094. eCollection 2026.

ABSTRACT

Pulmonary fibrosis (PF) significantly increases the risk of lung cancer (LC), but the mechanisms underlying this transition remain unclear. This overview positions macrophage heterogeneity as a central node within the PF-LC continuum. First, we describe important subpopulations of profibrotic and pro-tumor macrophages, including SPP1+, MERTK+, TREM2+, and MARCO+ cells, using high-resolution spatial and single-cell omics technologies. Next, we analyze the fundamental mechanisms that determine their function: the fibrotic microenvironment (e.g., extracellular matrix stiffness, hypoxia) induces profound metabolic reprogramming (e.g., Warburg effect, lipid peroxidation) and stabilizes epigenetic memory (e.g., DNA methylation, histone modifications), locking them into a pathogenic state. This reprogramming occurs through two main pathways: (1) metabolic reprogramming, characterized by aerobic glycolytic conversion and dysregulated lipid metabolism, which stimulates both pathogenic functions and suppression of T cell activity; (2) Epigenetic modifications, including stabilized alterations in DNA methylation, histone modifications, and superactivator patterns, which maintain cells in a tumor-promoting phenotype. As central nodes of communication, these macrophages interact pathologically with fibroblasts and epithelial cells through secreted factors and extracellular vesicles, forming self-reinforcing feedback loops that promote disease progression. We are studying the crucial role of new technologies, particularly multi-omic spatial models and high-precision organoids, in fostering mechanistic discoveries. These discoveries pave the way for new macrophage-focused therapeutic strategies, including the precise stratification of patients using biomarkers from liquid biopsies (such as soluble SPP1 and MARCO) and the development of targeted drug delivery systems for the selective modulation of macrophage function, thus establishing a new paradigm for therapeutic interventions in pulmonary fibrosis with concomitant lung cancer.

PMID:41939908 | PMC:PMC13046558 | DOI:10.3389/fimmu.2026.1787094

Decoding macrophage heterogeneity in the pulmonary fibrosis lung cancer transition

✇Omics In Lung
By: Hanming Yu · Mengmeng Zhao · Qiuhong Li · Yuan Zhang
6 April 2026 at 18:00

Front Immunol. 2026 Mar 20;17:1787094. doi: 10.3389/fimmu.2026.1787094. eCollection 2026.

ABSTRACT

Pulmonary fibrosis (PF) significantly increases the risk of lung cancer (LC), but the mechanisms underlying this transition remain unclear. This overview positions macrophage heterogeneity as a central node within the PF-LC continuum. First, we describe important subpopulations of profibrotic and pro-tumor macrophages, including SPP1+, MERTK+, TREM2+, and MARCO+ cells, using high-resolution spatial and single-cell omics technologies. Next, we analyze the fundamental mechanisms that determine their function: the fibrotic microenvironment (e.g., extracellular matrix stiffness, hypoxia) induces profound metabolic reprogramming (e.g., Warburg effect, lipid peroxidation) and stabilizes epigenetic memory (e.g., DNA methylation, histone modifications), locking them into a pathogenic state. This reprogramming occurs through two main pathways: (1) metabolic reprogramming, characterized by aerobic glycolytic conversion and dysregulated lipid metabolism, which stimulates both pathogenic functions and suppression of T cell activity; (2) Epigenetic modifications, including stabilized alterations in DNA methylation, histone modifications, and superactivator patterns, which maintain cells in a tumor-promoting phenotype. As central nodes of communication, these macrophages interact pathologically with fibroblasts and epithelial cells through secreted factors and extracellular vesicles, forming self-reinforcing feedback loops that promote disease progression. We are studying the crucial role of new technologies, particularly multi-omic spatial models and high-precision organoids, in fostering mechanistic discoveries. These discoveries pave the way for new macrophage-focused therapeutic strategies, including the precise stratification of patients using biomarkers from liquid biopsies (such as soluble SPP1 and MARCO) and the development of targeted drug delivery systems for the selective modulation of macrophage function, thus establishing a new paradigm for therapeutic interventions in pulmonary fibrosis with concomitant lung cancer.

PMID:41939908 | PMC:PMC13046558 | DOI:10.3389/fimmu.2026.1787094

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