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Received — 13 April 2026 ⏭

Nature - Issue - nature.com science feeds
Population-scale repeat expansions elucidate disease risk and brain atrophy Vijay Kumar Pounraja · Jae Hoon Sul · Joseph Herman · Sean O’Keeffe · Veera Rajagopal · Xiaodong Bai · Michael D. Kessler · Neelroop Parikshak · Karl Landheer · Xingmin Zhang · Sean Yu · Lance Zhang · Michelle G. LeBlanc · Jennifer Rico-Varela · Frederic Grau · Sarah Wolf · Sriramkumar Sundaramoorthy · Farshid Sepehrband · Eli A. Stahl · Yuda Huo · Mohsin Ahmed · Susan Croll · Adam Buchanan · David J. Carey · Christa L. Martin · Michelle Meyer · Kyle Retterer · David Rolston · James R. Cerhan · Fergus J. Couch · Janet E. Olson · Nicholas B. Larson · Zachary S. Fredericksen · Mine Cicek · Joanna M. Biernacka · Victor M. Karpyak · Prashanthi Vemuri · Vijay K. Ramanan · Owen A. Ross · Mark A. Frye · Jeanette E. Eckel Passow · Robert R. Jenkins · Daniel H. Lachance · Kristen L. Drucker · Paul A. Decker · Matthew L. Kosel · Sarah A. McLaughlin · Kathryn J. Ruddy · Nicholas J. Boddicker · Wenan Chen · Suzette J. Bielinski · John C. Lieske · W. Michael Hooten · Lisa A. Boardman · Richard B. Kennedy · Andrew D. Badley · Sean C. Dowdy · Shariska Harrington · Gretchen E. G
Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10345-6Decreased brain volumes and increased NfL levels can be observed earlier than disease diagnosis in short-tandem-repeat-associated neurological diseases.
8 April 2026 at 08:00

Population-scale repeat expansions elucidate disease risk and brain atrophy

Nature - Issue - nature.com science feeds

By: Vijay Kumar Pounraja · Jae Hoon Sul · Joseph Herman · Sean O’Keeffe · Veera Rajagopal · Xiaodong Bai · Michael D. Kessler · Neelroop Parikshak · Karl Landheer · Xingmin Zhang · Sean Yu · Lance Zhang · Michelle G. LeBlanc · Jennifer Rico-Varela · Frederic Grau · Sarah Wolf · Sriramkumar Sundaramoorthy · Farshid Sepehrband · Eli A. Stahl · Yuda Huo · Mohsin Ahmed · Susan Croll · Adam Buchanan · David J. Carey · Christa L. Martin · Michelle Meyer · Kyle Retterer · David Rolston · James R. Cerhan · Fergus J. Couch · Janet E. Olson · Nicholas B. Larson · Zachary S. Fredericksen · Mine Cicek · Joanna M. Biernacka · Victor M. Karpyak · Prashanthi Vemuri · Vijay K. Ramanan · Owen A. Ross · Mark A. Frye · Jeanette E. Eckel Passow · Robert R. Jenkins · Daniel H. Lachance · Kristen L. Drucker · Paul A. Decker · Matthew L. Kosel · Sarah A. McLaughlin · Kathryn J. Ruddy · Nicholas J. Boddicker · Wenan Chen · Suzette J. Bielinski · John C. Lieske · W. Michael Hooten · Lisa A. Boardman · Richard B. Kennedy · Andrew D. Badley · Sean C. Dowdy · Shariska Harrington · Gretchen E. G

8 April 2026 at 08:00

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10345-6

Decreased brain volumes and increased NfL levels can be observed earlier than disease diagnosis in short-tandem-repeat-associated neurological diseases.