Normal view
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cs.AI, q-bio.NC updates on arXiv.org
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OrpQuant: Geometric Orthogonal Residual Projection for Multiplier-Free Power-of-Two Transformer Quantization
arXiv:2605.26092v1 Announce Type: cross Abstract: The deployment of Large Language Models (LLMs) and Vision Transformers (ViTs) on edge devices is significantly constrained by memory limitations and the critical timing bottlenecks introduced by dense Multiply-Accumulate (MAC) arrays. In the ultra-low bit regime, logarithmic Power-of-Two (PoT) quantization provides a hardware-efficient alternative by replacing MAC operations with bit-shifts. However, the non-uniform exponential lattice is inhere
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cs.AI, q-bio.NC updates on arXiv.org
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Rethinking the Comparison Unit in Sequence-Level Reinforcement Learning: An Equal-Length Paired Training Framework from Loss Correction to Sample Construction
arXiv:2604.17328v2 Announce Type: replace-cross Abstract: This paper investigates the length problem in sequence-level relative reinforcement learning. We observe that, although existing methods partially alleviate length-related phenomena, a more fundamental issue remains insufficiently characterized: the comparison units used during training lack inherent comparability. Building on this observation, we propose a new perspective: the length problem should not be viewed merely as a loss-scaling
Rethinking the Comparison Unit in Sequence-Level Reinforcement Learning: An Equal-Length Paired Training Framework from Loss Correction to Sample Construction
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cs.AI, q-bio.NC updates on arXiv.org
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Internalizing Outcome Supervision into Process Supervision: A New Paradigm for Reinforcement Learning for Reasoning
arXiv:2605.05226v2 Announce Type: replace-cross Abstract: The central challenge of reinforcement learning for reasoning lies not only in the sparsity of outcome-level supervision, but more fundamentally in how to transform feedback provided only at the end of a sequence into fine-grained learning signals that can guide intermediate reasoning steps. Existing approaches either rely on outcome-level rewards for sequence-level optimization, which makes precise credit assignment difficult, or depend
Internalizing Outcome Supervision into Process Supervision: A New Paradigm for Reinforcement Learning for Reasoning
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Cell Death Discovery nature.com science feeds
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Activation of methionine metabolism mediated by HNF4α confers ferroptosis resistance in hepatocellular carcinoma
Cell Death Discovery, Published online: 26 May 2026; doi:10.1038/s41420-026-03165-0Activation of methionine metabolism mediated by HNF4α confers ferroptosis resistance in hepatocellular carcinoma
Activation of methionine metabolism mediated by HNF4α confers ferroptosis resistance in hepatocellular carcinoma
Cell Death Discovery, Published online: 26 May 2026; doi:10.1038/s41420-026-03165-0
Activation of methionine metabolism mediated by HNF4α confers ferroptosis resistance in hepatocellular carcinoma-
Pulmonary nodule
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Integrated single-cell and bulk RNA sequencing reveals novel biomarkers of invasive adenocarcinoma subtypes in lung adenocarcinoma
Transl Cancer Res. 2026 Apr 30;15(4):314. doi: 10.21037/tcr-2025-aw-2503. Epub 2026 Mar 20.ABSTRACTBACKGROUND: Lung adenocarcinoma (LUAD) is one of the most common lung cancer subtypes worldwide, and its aggressive subtype invasive adenocarcinoma (IAC) has low survival rates. The precise identification of IAC is vital for the clinical diagnosis and treatment. The purpose of this study is to identify novel biomarkers for LUAD using single-cell and bulk RNA sequencing, so as to provide theoretical
Integrated single-cell and bulk RNA sequencing reveals novel biomarkers of invasive adenocarcinoma subtypes in lung adenocarcinoma
Transl Cancer Res. 2026 Apr 30;15(4):314. doi: 10.21037/tcr-2025-aw-2503. Epub 2026 Mar 20.
ABSTRACT
BACKGROUND: Lung adenocarcinoma (LUAD) is one of the most common lung cancer subtypes worldwide, and its aggressive subtype invasive adenocarcinoma (IAC) has low survival rates. The precise identification of IAC is vital for the clinical diagnosis and treatment. The purpose of this study is to identify novel biomarkers for LUAD using single-cell and bulk RNA sequencing, so as to provide theoretical basis and practical support for the diagnosis, treatment and prognosis evaluation of lung invasive adenocarcinoma.
METHODS: We employed a combination of transcriptomic analysis and single-cell analysis to investigate the molecular characteristics and immune microenvironment of four subtypes of LUAD, including atypical adenomatous hyperplasia (AAH), adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), and IAC, with the aim of screening for biomarkers to differentiate pre-invasive lesions from invasive lesions.
RESULTS: Transcriptomic and single-cell analyses revealed that IAC subtypes demonstrated the most substantial molecular differences, particularly in immune cell infiltration and immune-related gene expression. Three genes-CD27, TIGIT, and TNFRSF18-that were significantly upregulated in IAC, predominantly expressed in immune cells and closely linked to immune regulatory pathways. We further analyzed T cell subpopulations in the IAC subtype and explored the expression of transcription factors (TFs) corresponding to these three genes, revealing their critical roles in immune cell function. Additionally, communication between T cells and other cells showed significantly enhanced signaling pathways, particularly those related to immune co-stimulatory molecules and inflammation pathways. Immunohistochemical validation of clinical samples showed that these three genes have high diagnostic value in IAC subtypes. These findings establish a crucial biological foundation for diagnosis, classification, and immunotherapy of LUAD, which contributes to the development of individualized treatment strategies.
CONCLUSIONS: This study identifies a three-gene signature (CD27, TIGIT, and TNFRSF18) that not only distinguishes invasive from pre-invasive LUAD with high precision by capturing the immune checkpoint disequilibrium characteristic of IAC, but also provides a clinically actionable biomarker panel for preoperative diagnosis and personalized immunotherapy strategies.
PMID:42180871 | PMC:PMC13190665 | DOI:10.21037/tcr-2025-aw-2503
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Nature - Issue - nature.com science feeds
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Carbonyl swapping converts cyclic ketones to saturated heterocycles
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10508-5Carbonyl swapping converts cyclic ketones to saturated heterocycles
Carbonyl swapping converts cyclic ketones to saturated heterocycles
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10508-5
Carbonyl swapping converts cyclic ketones to saturated heterocycles-
Nature - Issue - nature.com science feeds
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Can China’s Great Green Wall shape efforts to keep the world’s deserts at bay?
Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-01102-wGrand anti-desertification schemes often fail when trees die and funding dries up — yet one project has broken the mould.
Can China’s Great Green Wall shape efforts to keep the world’s deserts at bay?
Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-01102-w
Grand anti-desertification schemes often fail when trees die and funding dries up — yet one project has broken the mould.