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DisDop: Distillation with Domain Priors for Open-Vocabulary Aerial Object Detection

arXiv:2605.24639v1 Announce Type: cross Abstract: With the widespread application of drones in recent years, object detection of aerial images has attracted increasing attention, especially open-vocabulary aerial detection which is not restricted to predefined categories. Due to the scarcity of drone's viewpoint images and their significant differences from natural images, it is difficult to achieve satisfying results by directly applying vanilla open-vocabulary detection methods designed for natural scenarios. Some studies propose to transfer knowledge from pre-trained models by using lightweight networks or generating pseudo labels, but they tend to rely on models trained on natural images, neglecting the potential of foundation models specifically tailored for remote sensing and aerial imagery. To address this limitation, we propose DisDop, a unified framework that systematically distills multi-level domain priors from remote sensing foundation models (e.g., RemoteCLIP and DINOv3) into a lightweight detector. Specifically, we first distill visual priors through a teacher fusion strategy that combines RemoteCLIP's cross-modal alignment capability with DINOv3's fine-grained local feature extraction ability, transferring their complementary strengths to the detector's backbone. Second, we distill textual priors embedded in RemoteCLIP's text encoder by explicitly modeling inter-category semantic relationships, while incorporating global contextual priors to enhance local feature representation for small objects. Through this multi-level prior distillation framework, our DisDop achieves new state-of-the-art performance on open-vocabulary aerial detection benchmarks. Extensive ablation analysis also demonstrates the rationality and effectiveness of our proposed modules.

ATIC Promotes LIHC Progression and Serves as an Independent Prognostic Marker: A Pan-cancer Transcriptomic Analysis

Curr Mol Med. 2026 May 11. doi: 10.2174/0115665240438824260113042223. Online ahead of print.

ABSTRACT

BACKGROUND: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/ IMP cyclohydrolase(ATIC) is a 64-kDa bifunctional enzyme, 5-aminoimidazole- 4-carboxamide ribonucleotide formyltransferase (AICART) and IMP cyclohydrolase, respectively. catalyzes the last two steps of the purine ab initio biosynthetic pathway. ATIC has been implicated in cancer progression, but its pan-cancer profile and specific prognostic utility in liver hepatocellular carcinoma (LIHC) remain incompletely defined.

METHODS: We analyzed TCGA RNA-seq data across 33 tumor types to assess ATIC expression, diagnostic performance (ROC/AUC), and prognostic associations (OS, DSS, PFI). We correlated ATIC expression with immune infiltration, TMB, MSI, and predicted neoantigen load, and constructed a LIHC-specific prognostic nomogram integrating ATIC and clinicopathologic features. Enrichment analyses (STRING, GO/KEGG, GSEA) and pharmacogenomic correlations (GDSC, CTRP) were performed to explore mechanisms and drug sensitivities.

RESULTS: ATIC was significantly upregulated in 16 tumor types, including LIHC (p<0.001). Pan-cancer ROC analyses showed high diagnostic accuracy in several cancers (examples: CHOL AUC=1.000, LIHC AUC=0.936, LUAD AUC=0.947). High ATIC expression associated with poorer OS in ACC, HNSC, LIHC, and PAAD (eg, LIHC: HR=1.39(1.04-1.85), p=0.028). In LIHC, ATIC correlated with advanced T stage, higher grade, elevated AFP, and shorter OS. Multivariable Cox regression identified ATIC expression and pathological T stage as independent predictors; time-dependent ROC for the LIHC nomogram showed AUCs of 0.711, 0.649, and 0.653 at 1, 3, and 5 years, respectively. GSEA indicated enrichment of PI3K-AKT-mTOR, MYC targets, and cell-cycle pathways in ATIC-high LIHC. High ATIC expression correlated with predicted increased sensitivity to sorafenib, doxorubicin, cisplatin, epothilone, and mitomycin in the TCGA-LIHC cohort.

DISCUSSION: ATIC upregulation across cancers links to tumor progression, immune modulation, and prognosis (LIHC), suggesting oncogenic roles in pan-cancer contexts. TCGA multi-omics show ATIC associates with immune/molecular subtypes, MSI/TMB/neoantigens, and predicts drug sensitivity, indicating diagnostic/prognostic potential.

CONCLUSION: ATIC is broadly upregulated across cancers and functions as an independent prognostic biomarker in LIHC. The ATIC-integrated nomogram shows modest predictive accuracy for LIHC survival. Our results implicate ATIC in oncogenic signaling (PI3K-AKT-mTOR, MYC, and cell-cycle) and suggest ATIC as a candidate biomarker to guide targeted and chemotherapeutic strategies in LIHC. Further in vitro and in vivo validation is warranted.

PMID:42152649 | DOI:10.2174/0115665240438824260113042223

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