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Received — 27 May 2026 ⏭

Nature - Issue - nature.com science feeds
Mapping convergent regulators of melanoma drug resistance by PerturbFate Zihan Xu · Ziyu Lu · Aileen Ugurbil · Abdulraouf Abdulraouf · Andrew Liao · Jianxiang Zhang · Wei Zhou · Junyue Cao
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10367-0PerturbFate is a high-throughput, cost-effective, single-cell platform that systematically profiles CRISPR interference perturbations to reveal common regulatory nodes and convergent phenotypic states across diverse genetic alterations linked to vemurafenib resistance in melanoma cells.
15 April 2026 at 08:00

Mapping convergent regulators of melanoma drug resistance by PerturbFate

Nature - Issue - nature.com science feeds

By: Zihan Xu · Ziyu Lu · Aileen Ugurbil · Abdulraouf Abdulraouf · Andrew Liao · Jianxiang Zhang · Wei Zhou · Junyue Cao

15 April 2026 at 08:00

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10367-0

PerturbFate is a high-throughput, cost-effective, single-cell platform that systematically profiles CRISPR interference perturbations to reveal common regulatory nodes and convergent phenotypic states across diverse genetic alterations linked to vemurafenib resistance in melanoma cells.