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MemForest: An Efficient Agent Memory System with Hierarchical Temporal Indexing

arXiv:2605.23986v1 Announce Type: cross Abstract: Memory is a fundamental component for enabling long-context LLM agents, supporting persistent state across interactions through a continuous serve-and-update lifecycle. Despite substantial prior work, existing systems suffer from significant maintenance overhead due to two key limitations: coarse-grained state management and inherently sequential update pipelines. In particular, updates are often tightly coupled with LLM inference and require full-state rewrites, leading to poor scalability and growing latency as memory accumulates. To address these challenges, we present MemForest, a memory framework that reformulates agent memory as a write-efficient temporal data management problem. MemForest breaks the sequential bottleneck via parallel chunk extraction, decoupling memory construction into concurrent, independent operations. To further eliminate coarse-grained maintenance, we introduce MemTree, a hierarchical temporal index that organizes memory as time-ordered trees rather than flat global summaries. This design replaces full-state rewrites with localized per-node updates, reducing maintenance cost to the affected tree paths while naturally preserving temporally evolving states. We evaluate MemForest on two long-context memory benchmarks, LongMemEval-S and LoCoMo. On LongMemEval-S, MemForest achieves the best overall performance among stateful baselines, reaching 79.8% pass@1 accuracy while sustaining a memory construction throughput approximately 6x higher than state-of-the-art approaches including EverMemOS.

SaaS-Bench: Can Computer-Use Agents Leverage Real-World SaaS to Solve Professional Workflows?

arXiv:2605.15777v2 Announce Type: replace Abstract: Computer-Using Agents (CUAs) are rapidly extending large language models (LLMs) beyond text-based reasoning toward action execution in more complex environments, such as web browsers and graphical user interfaces (GUIs). However, existing web and GUI agent benchmarks often rely on simplified settings, isolated tasks, or short-horizon interactions, making it difficult to assess capabilities of agents in realistic professional workflows. Software-as-a-Service (SaaS) environments are a natural choice for CUA evaluation, as they host a large share of modern digital work and naturally involve dynamic system states, cross-application coordination, domain-specific knowledge, and long-horizon dependencies. To this end, we introduce SaaS-Bench, a benchmark built on 23 deployable SaaS systems across six professional domains, containing 106 tasks grounded in realistic work scenarios. These tasks require long-horizon execution, cover both text-only and multimodal settings, and are evaluated with weighted verification checkpoints that measure strict task completion and partial progress. Experiments show that representative LLM-based agents struggle on SaaS-Bench, with even the strongest model completing fewer than 4% of tasks end-to-end, exposing limitations in planning, state tracking, cross-application context maintenance, and error recovery. Code are available at https://github.com/UniPat-AI/SaaS-Bench for reproduction.

Integrated single-cell and bulk RNA sequencing reveals novel biomarkers of invasive adenocarcinoma subtypes in lung adenocarcinoma

Transl Cancer Res. 2026 Apr 30;15(4):314. doi: 10.21037/tcr-2025-aw-2503. Epub 2026 Mar 20.

ABSTRACT

BACKGROUND: Lung adenocarcinoma (LUAD) is one of the most common lung cancer subtypes worldwide, and its aggressive subtype invasive adenocarcinoma (IAC) has low survival rates. The precise identification of IAC is vital for the clinical diagnosis and treatment. The purpose of this study is to identify novel biomarkers for LUAD using single-cell and bulk RNA sequencing, so as to provide theoretical basis and practical support for the diagnosis, treatment and prognosis evaluation of lung invasive adenocarcinoma.

METHODS: We employed a combination of transcriptomic analysis and single-cell analysis to investigate the molecular characteristics and immune microenvironment of four subtypes of LUAD, including atypical adenomatous hyperplasia (AAH), adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), and IAC, with the aim of screening for biomarkers to differentiate pre-invasive lesions from invasive lesions.

RESULTS: Transcriptomic and single-cell analyses revealed that IAC subtypes demonstrated the most substantial molecular differences, particularly in immune cell infiltration and immune-related gene expression. Three genes-CD27, TIGIT, and TNFRSF18-that were significantly upregulated in IAC, predominantly expressed in immune cells and closely linked to immune regulatory pathways. We further analyzed T cell subpopulations in the IAC subtype and explored the expression of transcription factors (TFs) corresponding to these three genes, revealing their critical roles in immune cell function. Additionally, communication between T cells and other cells showed significantly enhanced signaling pathways, particularly those related to immune co-stimulatory molecules and inflammation pathways. Immunohistochemical validation of clinical samples showed that these three genes have high diagnostic value in IAC subtypes. These findings establish a crucial biological foundation for diagnosis, classification, and immunotherapy of LUAD, which contributes to the development of individualized treatment strategies.

CONCLUSIONS: This study identifies a three-gene signature (CD27, TIGIT, and TNFRSF18) that not only distinguishes invasive from pre-invasive LUAD with high precision by capturing the immune checkpoint disequilibrium characteristic of IAC, but also provides a clinically actionable biomarker panel for preoperative diagnosis and personalized immunotherapy strategies.

PMID:42180871 | PMC:PMC13190665 | DOI:10.21037/tcr-2025-aw-2503

A pathogen lncRNA secreted into rice sequesters a host miRNA for virulence

Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10572-x

A fungal long non-coding RNA from Magnaporthe oryzae translocates into rice cells to sequester a host microRNA that normally represses PKR1, a negative immunity regulator, thereby facilitating infection and revealing a widespread RNA-based pathogen–host interaction mechanism.

ATIC Promotes LIHC Progression and Serves as an Independent Prognostic Marker: A Pan-cancer Transcriptomic Analysis

Curr Mol Med. 2026 May 11. doi: 10.2174/0115665240438824260113042223. Online ahead of print.

ABSTRACT

BACKGROUND: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/ IMP cyclohydrolase(ATIC) is a 64-kDa bifunctional enzyme, 5-aminoimidazole- 4-carboxamide ribonucleotide formyltransferase (AICART) and IMP cyclohydrolase, respectively. catalyzes the last two steps of the purine ab initio biosynthetic pathway. ATIC has been implicated in cancer progression, but its pan-cancer profile and specific prognostic utility in liver hepatocellular carcinoma (LIHC) remain incompletely defined.

METHODS: We analyzed TCGA RNA-seq data across 33 tumor types to assess ATIC expression, diagnostic performance (ROC/AUC), and prognostic associations (OS, DSS, PFI). We correlated ATIC expression with immune infiltration, TMB, MSI, and predicted neoantigen load, and constructed a LIHC-specific prognostic nomogram integrating ATIC and clinicopathologic features. Enrichment analyses (STRING, GO/KEGG, GSEA) and pharmacogenomic correlations (GDSC, CTRP) were performed to explore mechanisms and drug sensitivities.

RESULTS: ATIC was significantly upregulated in 16 tumor types, including LIHC (p<0.001). Pan-cancer ROC analyses showed high diagnostic accuracy in several cancers (examples: CHOL AUC=1.000, LIHC AUC=0.936, LUAD AUC=0.947). High ATIC expression associated with poorer OS in ACC, HNSC, LIHC, and PAAD (eg, LIHC: HR=1.39(1.04-1.85), p=0.028). In LIHC, ATIC correlated with advanced T stage, higher grade, elevated AFP, and shorter OS. Multivariable Cox regression identified ATIC expression and pathological T stage as independent predictors; time-dependent ROC for the LIHC nomogram showed AUCs of 0.711, 0.649, and 0.653 at 1, 3, and 5 years, respectively. GSEA indicated enrichment of PI3K-AKT-mTOR, MYC targets, and cell-cycle pathways in ATIC-high LIHC. High ATIC expression correlated with predicted increased sensitivity to sorafenib, doxorubicin, cisplatin, epothilone, and mitomycin in the TCGA-LIHC cohort.

DISCUSSION: ATIC upregulation across cancers links to tumor progression, immune modulation, and prognosis (LIHC), suggesting oncogenic roles in pan-cancer contexts. TCGA multi-omics show ATIC associates with immune/molecular subtypes, MSI/TMB/neoantigens, and predicts drug sensitivity, indicating diagnostic/prognostic potential.

CONCLUSION: ATIC is broadly upregulated across cancers and functions as an independent prognostic biomarker in LIHC. The ATIC-integrated nomogram shows modest predictive accuracy for LIHC survival. Our results implicate ATIC in oncogenic signaling (PI3K-AKT-mTOR, MYC, and cell-cycle) and suggest ATIC as a candidate biomarker to guide targeted and chemotherapeutic strategies in LIHC. Further in vitro and in vivo validation is warranted.

PMID:42152649 | DOI:10.2174/0115665240438824260113042223

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