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cs.AI, q-bio.NC updates on arXiv.org
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Geo-Expert: Towards Expert-Level Geological Reasoning via Parameter-Efficient Fine-Tuning
arXiv:2605.24844v1 Announce Type: new Abstract: While general-purpose Large Language Models (LLMs) applied to Geology often hallucinate when reasoning about subsurface structures and deep-time evolution, current AI in Earth sciences predominantly targets surface remote sensing and GIS. To bridge this gap, we introduce Geo-Expert, a family of parameter-efficient geological LLMs fine-tuned on a custom-curated, high-quality instruction dataset processed using our custom instruction synthesis pipel
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cs.AI, q-bio.NC updates on arXiv.org
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Distributionally Robust Transfer Learning with Structurally Missing Covariates, with Application to Cross-National Cardiac Arrest Prediction
arXiv:2605.24212v1 Announce Type: cross Abstract: Deploying clinical prediction models across healthcare systems often fails when key training covariates are unavailable at deployment and labeled outcomes are limited in the target domain. For example, high-performing models for out-of-hospital cardiac arrest (OHCA) rely on detailed prehospital measurements routinely collected in high-resource settings but unavailable in many international registries. Existing methods either discard missing cova
Distributionally Robust Transfer Learning with Structurally Missing Covariates, with Application to Cross-National Cardiac Arrest Prediction
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cs.AI, q-bio.NC updates on arXiv.org
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Cross-Domain Energy-Guided Diffusion Generation for Off-Dynamics Reinforcement Learning
arXiv:2605.24810v1 Announce Type: cross Abstract: Off-dynamics offline reinforcement learning seeks to learn a target-domain policy from a large source dataset and a limited target dataset under mismatched transition dynamics. Existing approaches such as reward augmentation and data filtering are constrained to the source dataset and cannot synthesize new target behavior to improve coverage beyond the collected source trajectories. While recent model-based methods attempt to address this by lea
Cross-Domain Energy-Guided Diffusion Generation for Off-Dynamics Reinforcement Learning
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cs.AI, q-bio.NC updates on arXiv.org
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DRScaffold: Boosting Dense-Scene Reasoning in Lightweight Vision Language Models
arXiv:2605.26038v1 Announce Type: cross Abstract: Lightweight vision-language models perform competitively on standard benchmarks yet fail systematically in dense-scene reasoning, where multiple objects, attributes, and relations must be jointly grounded and resolved through multi-step inference. Such capability is critical for real-world applications where models must reliably interpret cluttered environments. Yet existing training signals provide no explicit grounding between reasoning steps
DRScaffold: Boosting Dense-Scene Reasoning in Lightweight Vision Language Models
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cs.AI, q-bio.NC updates on arXiv.org
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AutoResearchClaw: Self-Reinforcing Autonomous Research with Human-AI Collaboration
arXiv:2605.20025v2 Announce Type: replace Abstract: Automating scientific discovery requires more than generating papers from ideas. Real research is iterative: hypotheses are challenged from multiple perspectives, experiments fail and inform the next attempt, and lessons accumulate across cycles. Existing autonomous research systems often model this process as a linear pipeline: they rely on single-agent reasoning, stop when execution fails, and do not carry experience across runs. We present
AutoResearchClaw: Self-Reinforcing Autonomous Research with Human-AI Collaboration
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cs.AI, q-bio.NC updates on arXiv.org
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SoK: A Comprehensive Security Analysis of Jailbreak Resilience in GPT and DeepSeek Models
arXiv:2506.18543v2 Announce Type: replace-cross Abstract: The rapid proliferation of Large Language Models (LLMs) has heightened concerns regarding their exposure to jailbreak attacks, which craft adversarial inputs designed to elicit unsafe content. Although proprietary models such as GPT-4 have been extensively evaluated, the robustness of emerging open-source systems like DeepSeek remains insufficiently examined, despite their growing use in LLM applications. In this paper, we conduct the fi
SoK: A Comprehensive Security Analysis of Jailbreak Resilience in GPT and DeepSeek Models
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cs.AI, q-bio.NC updates on arXiv.org
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STAPO: Stabilizing Reinforcement Learning for LLMs by Silencing Rare Spurious Tokens
arXiv:2602.15620v5 Announce Type: replace-cross Abstract: Reinforcement Learning (RL) has significantly improved large language model reasoning, but existing RL fine-tuning methods rely heavily on heuristic techniques such as entropy regularization and reweighting to maintain stability. In practice, they often suffer from late-stage performance collapse, leading to degraded reasoning quality and unstable training. We identify a key factor behind this instability: a small fraction of tokens, ter
STAPO: Stabilizing Reinforcement Learning for LLMs by Silencing Rare Spurious Tokens
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Pulmonary nodule
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Proteomic and lipidomic analyses reveal molecular subtypes and potential targets in early-stage lung adenocarcinoma among non-smokers
Cell Rep. 2026 May 26;45(5):117215. doi: 10.1016/j.celrep.2026.117215. Epub 2026 Apr 28.ABSTRACTEarly-stage lung adenocarcinoma (LUAD) in never smokers exhibits distinct biological features, yet the metabolic programs driving early invasion remain unclear. We integrate proteomic and lipidomic profiling of primary LUAD tumors from never smokers, matched normal adjacent tissues (NATs), and benign pulmonary nodules (BPNs). Integrated multi-omics analysis reveals coordinated dysregulation of lipid m
Proteomic and lipidomic analyses reveal molecular subtypes and potential targets in early-stage lung adenocarcinoma among non-smokers
Cell Rep. 2026 May 26;45(5):117215. doi: 10.1016/j.celrep.2026.117215. Epub 2026 Apr 28.
ABSTRACT
Early-stage lung adenocarcinoma (LUAD) in never smokers exhibits distinct biological features, yet the metabolic programs driving early invasion remain unclear. We integrate proteomic and lipidomic profiling of primary LUAD tumors from never smokers, matched normal adjacent tissues (NATs), and benign pulmonary nodules (BPNs). Integrated multi-omics analysis reveals coordinated dysregulation of lipid metabolism and immune signaling in early LUAD. Proteome-based network fusion stratifies invasive LUAD into immune-metabolic synergistic (IMS) and metabolic-stress-driven (MSD) subtypes. IMS tumors retain apolipoprotein-associated lipid modules and favorable immune features, whereas MSD tumors exhibit stress-response programs. Mechanistically, APOA1 and APOC1 emerge as key nodes linking lipid homeostasis to invasion, and their depletion promotes LUAD cell migration and invasion. We establish a two-protein, four-lipid diagnostic panel demonstrating robust performance across tissue and plasma cohorts. These findings provide a molecular basis for early detection and risk stratification in never smokers.
PMID:42054209 | DOI:10.1016/j.celrep.2026.117215