❌

Normal view

Received β€” 27 May 2026 ⏭

DemoEvolve: Overcoming Sparse Feedback in Agentic Harness Evolution with Demonstrations

βœ‡cs.AI, q-bio.NC updates on arXiv.org
By: Lirong Che Β· Yuzhe yang Β· Peiwen lin Β· Chuang wang Β· Xueqian wang Β· Jian su
26 May 2026 at 12:00
arXiv:2605.24539v1 Announce Type: new Abstract: Agent harness evolution improves frozen language-model agents by modifying the executable structures around them. We study this paradigm as a form of sample-efficient fast adaptation: instead of updating model weights, an agent can acquire task-specific competence by changing its external harness, while leaving the base model's general capabilities intact. Prior work shows that self-generated rollouts can support harness search, suggesting that agents may acquire new task competence through practice. Yet in long-horizon stochastic environments, self-practice becomes fragile: rewards are sparse, outcomes are high-variance, and failures are hard to attribute to concrete harness mechanisms. We introduce DemoEvolve, a demonstration-bootstrapped approach to harness evolution. When reward-only search is too broad and noisy, competent human trajectories serve as expert reference experience for the coding proposer, guiding harness-level diagnosis and editing. Experiments on Liar's Dice show that self-rollout evolution can work when episodes are short and failures are attributable. In contrast, Balatro exposes a harder long-horizon stochastic regime, where self-rollout evolution is misled by sparse feedback and candidate-selection noise, while tutorial-like textual knowledge alone does not yield stable improvement. Under the same limited budget, DemoEvolve produces more effective and auditable harness edits and achieves better performance. Overall, demonstrations make sparse-feedback harness evolution more diagnosable, localizable, and stable.

Turning Stale Gradients into Stable Gradients: Coherent Coordinate Descent with Implicit Landscape Smoothing for Lightweight Zeroth-Order Optimization

βœ‡cs.AI, q-bio.NC updates on arXiv.org
By: Chen Liang Β· Xiatao Sun Β· Qian Wang Β· Daniel Rakita
26 May 2026 at 12:00
arXiv:2605.14373v2 Announce Type: replace-cross Abstract: Zeroth-Order (ZO) optimization is pivotal for scenarios where backpropagation is unavailable, such as memory-constrained on-device learning and black-box optimization. However, existing methods face a stark trade-off: they are either sample-inefficient (e.g., standard finite differences) or suffer from high variance due to randomized estimation (e.g., random subspace methods). In this work, we propose Coherent Coordinate Descent (CoCD), a deterministic, sample-efficient, and budget-aware ZO optimizer. Theoretically, we formalize the notion of gradient coherence and demonstrate that CoCD is equivalent to Block Cyclic Coordinate Descent (BCCD) with ``warm starts,'' effectively converting historical (stale) gradients from a liability into a computational asset. This mechanism enables $O(1)$ query complexity per step while maintaining global descent directions. Furthermore, we derive error bounds revealing a counter-intuitive insight: larger finite-difference step sizes can induce an implicit smoothing effect on the optimization landscape by reducing the effective smoothness constant, thereby improving convergence stability. Experiments on MLP, CNN, and ResNet architectures (up to 270k parameters) demonstrate that CoCD significantly outperforms BCCD in terms of sample efficiency and convergence loss/accuracy, and exhibits superior stability over randomized ZO methods. Our results suggest that deterministic, structure-aware updates offer a superior alternative to randomization for lightweight ZO optimization.

Multi-omics integration identifies ribosome biogenesis-active macrophage subpopulation and its key gene GNL2 in driving liver hepatocellular carcinoma progression and mechanisms

βœ‡Omics in Hepatocellular
By: Yajie Qi Β· Kun Li Β· Pincheng Li Β· Jianyu Yan Β· Shuyue Feng Β· Dan Wan Β· Ke Du Β· Xiao Liang Β· Fan Yang Β· Erzheng Zhou Β· Na Huang Β· Qian Wang Β· Nanbin Liu
14 May 2026 at 18:00

Cancer Cell Int. 2026 May 14. doi: 10.1186/s12935-026-04330-2. Online ahead of print.

ABSTRACT

BACKGROUND: Liver hepatocellular carcinoma (LIHC) is a common malignancy, yet the core genes driving its progression and potential therapeutic targets remain insufficiently explored. Ribosome biogenesis (RB) is a critical biological process linked to various cancers; however, its systematic role in LIHC remains unclear.

METHODS: This study integrated LIHC single-cell RNA-Seq, bulk RNA-Seq, and spatial transcriptomic data with ribosome biogenesis-related gene sets to construct a single-cell atlas of LIHC. Weighted Gene Co-expression Network Analysis (WGCNA) was employed to characterize myeloid cell subsets. Furthermore, an LIHC prognostic risk model based on RB-related genes was developed using 117 machine-learning algorithm combinations. Key findings were subsequently corroborated through experimental validation and clinical sample analysis.

RESULTS: We identified a distinct macrophage subpopulation with high ribosome biogenesis activity, termed ribosome biogenesis-active macrophages (RAMs). These cells exhibited strong communication with inflammatory macrophages, potentially mediated by MIF-related receptor-ligand interactions. We further constructed an 8-gene prognostic model (PA2G4, GNL2, PWP1, DDX49, NOC4L, GDI2, CST7, and RCL1), which showed good predictive performance. Drug sensitivity analysis suggested that the high-risk group may be more responsive to several agents, including docetaxel. Among these genes, GNL2 was selected for further investigation. Elevated GNL2 expression was associated with increased stemness features in myeloid cells. Molecular docking analysis identified several candidate compounds with potential binding affinity to GNL2. Functionally, GNL2 knockdown in macrophages reduced TGF-Ξ² and TNF-Ξ± expression and was associated with decreased proliferation, migration, and invasion of LIHC cells.

CONCLUSION: We identified a highly active ribosome biogenesis-macrophage subpopulation (RAM), and constructed a robust risk model to aid in the diagnosis, prognosis, and treatment of LIHC. GNL2 is associated with increased expression of TGF-Ξ² and TNF-Ξ± and may contribute to LIHC progression.

PMID:42135716 | DOI:10.1186/s12935-026-04330-2

There are no more articles
❌