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EditCaption: Human-Refined SFT and HAE-DPO for Image Editing Instruction Synthesis

arXiv:2604.08213v2 Announce Type: replace-cross Abstract: High-quality source-target image pairs with precise editing instructions are essential for instruction-guided image editing, yet constructing such training triplets at scale remains costly. Recent pipelines often rely on vision-language models to synthesize editing instructions automatically, but we find that strong VLMs still struggle to describe visual transformations between image pairs. In particular, they exhibit three recurring failure modes: orientation inconsistency, viewpoint ambiguity, and missing fine-grained attributes. In a human evaluation on 400 image pairs, several open-source VLM baselines produce critical-error rates above 47\%, making many synthesized instructions unsuitable for downstream training. To address this, we propose EditCaption, a two-stage post-training pipeline for image editing instruction synthesis. First, we construct a 100K supervised fine-tuning dataset through GLM-based auto-captioning, EditScore filtering, and human refinement. Second, we collect 10K human-annotated preference pairs, where each rejected instruction is labeled with its primary error type and severity. Based on this dataset, we propose Hardness-Adaptive Error-Aware DPO (HAE-DPO), a task-adapted DPO objective that introduces an adaptive margin based on human-labeled severity, failure-mode type, and reference-model hardness. Experiments across three benchmarks demonstrate that our 235B model with SFT+HAE-DPO achieves state-of-the-art performance among open-source and closed models, scoring 4.720 on Eval-400, 4.672 on HQ-Edit, and 4.651 on ByteMorph-Bench -- surpassing Gemini-3-Pro on all three. Human evaluation confirms critical error rates drop from 47.75\% to 17.50\%, with correct rates improving from 41.75\% to 70.25\%, surpassing Gemini-3-Pro (66.00\%).

Refined immune-based molecular subtypes of gastric cancer: Integrating mismatch repair status and tumor microenvironment for enhanced immunotherapy prediction

18 May 2026 at 18:00

Chin J Cancer Res. 2026 Apr 30;38(2):234-251. doi: 10.21147/j.issn.1000-9604.2026.02.09.

ABSTRACT

OBJECTIVE: Gastric cancer (GC) is heterogeneous, and current mismatch repair (MMR)-based classifications incompletely predict response to immune checkpoint inhibitors (ICIs).

METHODS: RNA sequencing (RNA-seq) and immune infiltration profiles from 189 resected GC were used to derive four refined immune-MMR subtypes (R1-R4) by integrating MMR status, survival, and tumor microenvironment (TME) features. Multi-omics profiling and pathway analysis defined subtype biology. External transcriptomic cohorts and an ICI-treated cohort were classified with Nearest Template Prediction (NTP). Immune response-associated genes were identified from responder vs. non-responder comparisons within the ICI-sensitive subtype and validated by multiplex immunohistochemistry (mIHC).

RESULTS: R1 showed the best prognosis and highest immunotherapy response with objective response rate (ORR) 54.5%, while R4 had the worst prognosis. R2 represented an immune-unresponsive deficient mismatch repair (dMMR) subset, and R3 captured an immune-active proficient mismatch repair (pMMR) subgroup with moderate therapy sensitivity. Multi-omics integration revealed subtype-specific pathways (e.g., ECM remodeling in R1, metabolic reprogramming in R2). Reclassification of pMMR tumors based on transcriptional similarity to R1 identified a New R3 subset with enhanced immune features and higher ICI response. Eight immune response-associated genes (e.g., CXCL10, CXCL11, ELN, GAD1, IL32, MT1E, OR2I1P, SLC3A1) were identified and validated by mIHC for predictive relevance.

CONCLUSIONS: This immune-based molecular framework refines risk stratification beyond conventional MMR categories, identifies ICI-sensitive subsets among both dMMR and pMMR tumors, and proposes candidate biomarkers for patient selection.

PMID:42147371 | PMC:PMC13171420 | DOI:10.21147/j.issn.1000-9604.2026.02.09

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