Normal view
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cs.AI, q-bio.NC updates on arXiv.org
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From Accuracy to Auditability: A Survey of Determinism in Financial AI Systems
arXiv:2605.23955v1 Announce Type: new Abstract: Deploying machine learning in regulated financial environments -- credit risk, fraud detection, and anti-money laundering -- exposes critical vulnerabilities in algorithmic reproducibility. While early financial ML addressed statistical challenges such as backtest overfitting, deep neural networks and Generative AI have introduced mechanical nondeterminism rooted in hardware and architecture. This survey provides a systems perspective on reproduci
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Omics In Lung
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Ginkgolic Acids Degradation by the <em>Ginkgo biloba</em> Endophytic Fungus <em>Fusarium</em> sp. DLT-118
Foods. 2026 Apr 6;15(7):1247. doi: 10.3390/foods15071247.ABSTRACTGinkgolic acids (GAs), the principal toxic constituents in Ginkgo biloba, pose health risks including cytotoxicity, allergenicity, and pro-inflammatory effects, limiting the application of Ginkgo resources in the food and health product industries. Developing efficient and environmentally friendly removal methods is essential. The endophytic fungus Fusarium sp. DLT-118, isolated from Ginkgo biloba, degraded 96.47% of GAs in Ginkgo
Ginkgolic Acids Degradation by the <em>Ginkgo biloba</em> Endophytic Fungus <em>Fusarium</em> sp. DLT-118
Foods. 2026 Apr 6;15(7):1247. doi: 10.3390/foods15071247.
ABSTRACT
Ginkgolic acids (GAs), the principal toxic constituents in Ginkgo biloba, pose health risks including cytotoxicity, allergenicity, and pro-inflammatory effects, limiting the application of Ginkgo resources in the food and health product industries. Developing efficient and environmentally friendly removal methods is essential. The endophytic fungus Fusarium sp. DLT-118, isolated from Ginkgo biloba, degraded 96.47% of GAs in Ginkgo biloba leaf extract (GE) at an initial concentration of 1 mg/mL within 7 days at 28 Β°C, while concurrently enhancing the antioxidant activity of GE, as indicated by a reduction in the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging IC50 from 755.7 ΞΌg/mL to 544.6 ΞΌg/mL. Morphological and oxidative stress analyses showed critical cellular adaptations and stress responses under degradation conditions. Integrated multi-omics analysis indicated that GE stress induced the remodeling of fungal amino acid, lipid, and energy metabolism, as well as the adjustment of membrane and transport functions, to facilitate GAs detoxification. Cytotoxicity assays indicated no significant cytotoxicity of the degradation products towards human normal lung epithelial cells (Beas-2B) and gastric mucosal epithelial cells (GES-1). These findings highlight Fusarium sp. DLT-118 as a promising agent for the efficient removal of GAs, offering a potential strategy for the production of GA-reduced Ginkgo-based food and health products.
PMID:41976541 | PMC:PMC13073844 | DOI:10.3390/foods15071247