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cs.AI, q-bio.NC updates on arXiv.org
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OSDTW: Optimal Shared Depth and Task Weighting for Long-Tailed Recognition
arXiv:2605.24969v1 Announce Type: cross Abstract: Long-tailed recognition suffers from a persistent head--tail trade-off: improving tail performance often degrades head accuracy and can increase training instability. Despite strong empirical results from re-weighting, decoupled training, and multi-expert methods, key design choices about representation sharing between head and tail classes and supervision weighting across class groups remain largely heuristic. In this work, we propose OSDTW, a
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Omics in Gastric
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An Orally Deliverable, Food-Compatible Lyophilized Recombinant Whole-Cell Catalyst for Alcohol-Associated Liver Injury
Microorganisms. 2026 Mar 26;14(4):746. doi: 10.3390/microorganisms14040746.ABSTRACTEffective oral interventions for alcohol-induced metabolic stress and liver injury remain limited. Pre-absorptive gastrointestinal alcohol handling is gaining interest as a non-pharmacological strategy to reduce hepatic burden. In this study, we developed a formulation-integrated, food-compatible lyophilized recombinant whole-cell catalyst based on Escherichia coli Nissle 1917 engineered to express alcohol dehydro
An Orally Deliverable, Food-Compatible Lyophilized Recombinant Whole-Cell Catalyst for Alcohol-Associated Liver Injury
Microorganisms. 2026 Mar 26;14(4):746. doi: 10.3390/microorganisms14040746.
ABSTRACT
Effective oral interventions for alcohol-induced metabolic stress and liver injury remain limited. Pre-absorptive gastrointestinal alcohol handling is gaining interest as a non-pharmacological strategy to reduce hepatic burden. In this study, we developed a formulation-integrated, food-compatible lyophilized recombinant whole-cell catalyst based on Escherichia coli Nissle 1917 engineered to express alcohol dehydrogenase and acetaldehyde dehydrogenase. Rather than focusing exclusively on strain-level genetic modification, the engineered cells were protected by lyophilization combined with a food-grade chitosan-alginate layer-by-layer coating, forming an artificial cell wall designed to enhance survivability during oral delivery. The formulation resisted simulated gastric acid, sodium taurocholate, and ethanol, retained enzymatic activity after storage, and demonstrated formulation stability. In alcohol-exposed mice, oral administration reduced blood ethanol and acetaldehyde levels, improved liver biochemical parameters, attenuated hepatic steatosis, and partially restored oxidative stress indicators. Integrated multi-omics analyses indicated coordinated gut-associated metabolic and inflammatory responses to alcohol and intervention, rather than a single dominant pathway. These findings provide hypothesis-generating evidence; causality remains to be established. Overall, this study demonstrates a proof-of-concept, food-compatible lyophilized recombinant whole-cell catalyst that integrates enzymatic function with formulation stability and gastrointestinal resilience, highlighting an applied, food-compatible microbial framework for exploring alcohol-related metabolic stress.
PMID:42075143 | PMC:PMC13119499 | DOI:10.3390/microorganisms14040746
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Cell
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An activated wheat CCG10-NLR immune receptor forms an octameric resistosome
An activated CCG10-NLR WAI3 plant immune receptor forms an octameric resistosome, which induces calcium influx and immune responses through a unique channel architecture.