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OSDTW: Optimal Shared Depth and Task Weighting for Long-Tailed Recognition

arXiv:2605.24969v1 Announce Type: cross Abstract: Long-tailed recognition suffers from a persistent head--tail trade-off: improving tail performance often degrades head accuracy and can increase training instability. Despite strong empirical results from re-weighting, decoupled training, and multi-expert methods, key design choices about representation sharing between head and tail classes and supervision weighting across class groups remain largely heuristic. In this work, we propose OSDTW, a principled task-decomposition framework that partitions the original single-label recognition problem into a head task and a tail task, implemented with a shared encoder and task-specific decoders. To handle the mutual exclusivity and statistical dependence between the two label groups, we introduce a factorized model and show that the resulting Kullback--Leibler divergence-based generalization error can be written as the sum of task-wise terms up to an additive constant, yielding a well-defined task-wise objective. We further develop a three-stage training pipeline: independent task training to estimate task-wise optima and the Fisher information matrix, weighted joint training to learn a shared encoder, and branch assembly to construct the final decoupled model. Under a block-diagonal Fisher approximation, we derive a computable second-order expansion of the expected generalization error, decomposing it into encoder variance, encoder bias, and decoder variance. This bias--variance decomposition provides a computable proxy to select the shared depth and task weights, enabling efficient hyper-parameter search. Experiments on standard long-tailed benchmarks demonstrate the effectiveness of the proposed approach over strong baselines.

An Orally Deliverable, Food-Compatible Lyophilized Recombinant Whole-Cell Catalyst for Alcohol-Associated Liver Injury

Microorganisms. 2026 Mar 26;14(4):746. doi: 10.3390/microorganisms14040746.

ABSTRACT

Effective oral interventions for alcohol-induced metabolic stress and liver injury remain limited. Pre-absorptive gastrointestinal alcohol handling is gaining interest as a non-pharmacological strategy to reduce hepatic burden. In this study, we developed a formulation-integrated, food-compatible lyophilized recombinant whole-cell catalyst based on Escherichia coli Nissle 1917 engineered to express alcohol dehydrogenase and acetaldehyde dehydrogenase. Rather than focusing exclusively on strain-level genetic modification, the engineered cells were protected by lyophilization combined with a food-grade chitosan-alginate layer-by-layer coating, forming an artificial cell wall designed to enhance survivability during oral delivery. The formulation resisted simulated gastric acid, sodium taurocholate, and ethanol, retained enzymatic activity after storage, and demonstrated formulation stability. In alcohol-exposed mice, oral administration reduced blood ethanol and acetaldehyde levels, improved liver biochemical parameters, attenuated hepatic steatosis, and partially restored oxidative stress indicators. Integrated multi-omics analyses indicated coordinated gut-associated metabolic and inflammatory responses to alcohol and intervention, rather than a single dominant pathway. These findings provide hypothesis-generating evidence; causality remains to be established. Overall, this study demonstrates a proof-of-concept, food-compatible lyophilized recombinant whole-cell catalyst that integrates enzymatic function with formulation stability and gastrointestinal resilience, highlighting an applied, food-compatible microbial framework for exploring alcohol-related metabolic stress.

PMID:42075143 | PMC:PMC13119499 | DOI:10.3390/microorganisms14040746

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