AAV-WM04, an AAV vector identified through in-vivo-directed screening in the adult cochlea, enables highly efficient and selective inner hair cell transduction. Dual-AAV delivery of OTOF using AAV-WM04 restores hearing in a DFNA9 deafness mouse model at low doses, highlighting its translational potential for gene therapy.

Nature Nanotechnology, Published online: 08 September 2026; doi:10.1038/s41565-026-02275-1

Structured light–matter interaction at the single-photon level is demonstrated in a coupled quantum-dot–micropillar system, enabling cavity-enhanced single-photon emission with spin-locked orbital angular momentum and tunable spin–orbit entanglement.

arXiv:2605.30002v2 Announce Type: replace Abstract: Cross-domain multimodal time series forecasting is a challenging task, requiring models to integrate precise numerical comprehension, cross-domain semantic understanding, and effective multimodal fusion. Existing approaches either build Time Series Foundation Models (TSFMs) from scratch or leverage pretrained Large Language Models (LLMs). However, TSFMs often overlook semantic understanding and lack the ability to perform future-oriented semantic reasoning, and LLMs struggle with numerical comprehension and accurate quantitative forecasting. To overcome these limitations, we propose KairosAgent, a novel agentic framework for multimodal time series forecasting, including an LLM-based reasoner and a TSFM-based forecaster. KairosAgent unifies textual reasoning and numerical forecasting by dynamically invoking analytical tools to enhance the numerical understanding and semantic reasoning capabilities of LLMs. The reasoning results are subsequently fused into the TSFM pipeline, enabling more accurate and reliable future predictions. To further improve the reasoning, we curate a large-scale corpus of high-quality trajectories, alongside a reinforcement learning from forecasting paradigm with multi-turn refinement and turn-level credit assignment. Experiments demonstrate that KairosAgent achieves superior zero-shot forecasting performance while maximizing the utility of pretrained LLMs and TSFMs, presenting a promising direction for efficient and interpretable time series agents. The project page is at https://foundation-model-research.github.io/KairosAgent .

arXiv:2608.30107v2 Announce Type: replace-cross Abstract: Understanding which countries are represented in NLP datasets is essential for identifying gaps, targeting data collection, measuring progress, and informing AI policy. However, geographic metadata is very rarely available, and country-level representation is often hidden behind broad language-level claims. We introduce AtlasNLP, a country-aware atlas of over 13,000 NLP dataset records across normalized NLP task categories, tracking both the populations represented and where datasets are produced. AtlasNLP includes AtlasNLP-Gold, a human-curated reference set, and AtlasNLP-Core, an ACL-derived large-scale collection. Using this resource, we show that (1) dataset coverage is highly uneven across countries and tasks; (2) dataset production and representation are geographically asymmetric; and (3) language coverage does not imply geographic representation. These findings reveal blind spots in current dataset documentation practices and motivate more explicit geographic metadata for country-aware NLP evaluation.

arXiv:2608.30935v2 Announce Type: replace-cross Abstract: Embodied navigation requires agents to translate heterogeneous goals and visual observations into actions across tasks, environments, and robot embodiments. Modern vision-language models (VLMs) already encode spatial priors for visual grounding, spatial reasoning, and pointing, but these capabilities are rarely elicited directly for robot control. Existing navigation systems instead rely on task- or embodiment-specific components, fragmenting perception, reasoning, and action while offering limited generalization. Here we present LightNav-0, a compact generalist embodied navigation model that elicits the spatial intelligence of a pretrained VLM and aligns it with navigation, without task-specific prediction heads. LightNav-0 represents diverse navigation tasks through a unified token interface: dual-channel pointing expresses task-, scene-, and embodiment-agnostic spatial intent, while a residual vector-quantized action tokenizer maps this intent to precise, embodiment-specific trajectories. Together with temporally aware visual history compression, ER mid-training, supervised fine-tuning, and reinforcement learning, this formulation supports instruction following, open-vocabulary object navigation, and visual tracking within a single model. The navigation training corpus spans 2K+ scenes and 4K+ hours of embodied navigation data. LightNav-ER, the embodied-reasoning checkpoint used to initialize LightNav-0, attains the highest complete-set average across 8 embodied-reasoning benchmarks, while LightNav-0 achieves state-of-the-art monocular success rates across all 10 public navigation simulation settings. Real-world evaluations further demonstrate zero-shot generalization across robot embodiments, diverse scenes, and static and dynamic targets. These results establish compact VLMs as a unified and transferable backbone for generalist embodied navigation.

arXiv:2609.07699v2 Announce Type: replace-cross Abstract: Curating Web corpora for regional language variants like European Portuguese (PT-PT) is heavily bottlenecked by dialectal overlap (mainly with PT-BR) and data processing scale. This paper presents an efficient pipeline to curate a production-ready PT-PT corpus from the Portuguese Web, spanning 411 TB of raw data from Arquivo.pt. We introduce a novel post-scraping block that removes boilerplate and line duplicates prior to filtering. This early-stage intervention increases final document yield by 19.04% by rescuing valid text that standard heuristic filters prematurely discard. Integrated with rigorous language identification, weighted fuzzy deduplication, and neural quality classification, our pipeline offers a scalable framework and a clean, representative corpus optimized for LLM pre-training.