He and colleagues developed a transient, non-gene-editing platform for off-the-shelf allogeneic TCR-T therapy. By conferring tacrolimus resistance characteristics to IL-2/4/7 expanded TCR-T cells that display reduced alloreactivity, He et al. provided a proof-of-concept for an allogeneic TCR-T therapy approach that addresses both manufacturability, and unwanted graft and host alloreactivity concerns.

arXiv:2609.10293v1 Announce Type: cross Abstract: In high-stakes domains such as legal practice, a language-model answer is only useful to the extent that a reader can verify each claim against the source the system cites. Current grounded-generation pipelines score the answer as a whole, so a correct conclusion can rest on fabricated or loosely matched citations and still score well. Closing this gap requires both a system built for per-claim verification and an evaluation that measures it. We introduce GANDR (Grounded ANswer DRafter), a two-agent system in which a Drafter writes an answer in a structured legal-reasoning format and a separate Critic, with the same view as a human verifier, audits each claim against its cited source and emits a per-claim audit trace on every round. We pair it with a strict correctness criterion requiring every citation to resolve to a passage the retriever returned. On a 185-item legal benchmark where all six systems share one backbone, one retrieval surface, and one citation instruction, GANDR ranks first on every primary metric, reaching 70.8% strict accuracy and leading the strongest baseline by 11.3 points (p

arXiv:2609.04355v2 Announce Type: replace-cross Abstract: Pretrained vision-language-action (VLA) models enable broad manipulation but remain unreliable in tasks demanding precision and repeatability. Applying real-world online reinforcement learning (RL) to VLA post-training enables autonomous trial-and-error improvement beyond demonstrations alone, but exposes two bottlenecks: 1) unreliable value signals can induce policy drift; 2) large-VLA overhead constrains throughput and sample efficiency. To address these challenges, we present VLA-Precision, an efficient real-world online RL framework featuring the Asymmetric Co-Bootstrapping (ACoB) algorithm and the ACoB-Stream architecture. Specifically, ACoB establishes asymmetric co-bootstrapping across timescales: early intervention-guided behavioral learning rapidly improves policy performance while enhancing online experience quality. As autonomous experience accumulates, global return propagation and local preference ranking progressively calibrate value estimates, yielding relative action advantages for reference-regularized policy improvement while suppressing drift. To enable ACoB on large VLAs, we develop ACoB-Stream, a closed-loop experience--policy architecture that establishes invariant-state decoupling and on-demand streaming as design principles, delivering up to 10.9$\times$ improvements in throughput and computational efficiency. Extensive evaluations on nine high-precision chemistry tasks across four categories and four robot embodiments show that VLA-Precision achieves 98.3\% mean success rate in 45.8 min/task, with 27.6 s episodes running at 1.2$\times$ and 1.8$\times$ the speeds of VLA and RL baselines. Resources are available at https://vla-precision.github.io.