Nature Nanotechnology, Published online: 08 September 2026; doi:10.1038/s41565-026-02262-6Charge-switching S-lipids generate S-lipid nanoparticles that are neutral or negative at physiological pH but become cationic in acidic endosomes, enabling nucleic acid delivery with reduced inflammation compared with conventional LNPs.

Nature Cancer, Published online: 25 August 2026; doi:10.1038/s43018-026-01221-3Chen and colleagues report that the neuropeptide galanin impairs antitumor immunity in glioblastoma by interacting with its receptor GALR3 on monocytic myeloid-derived suppressor cells, promoting their infiltration and ferroptosis resistance.