Yuan and colleagues demonstrate that inhaled biodegradable nanosilica activates an alveolar macrophage–NK axis, triggering an IL-12/15/18 triad that programs memory-like NK cells. This non-fibrotic, cell-free strategy suppresses melanoma growth, prevents postsurgical recurrence, and synergizes with anti-PD-1, establishing a robust framework for in vivo NK cell immunotherapy.

Liu and colleagues developed a robust in cellulo plasmid DNA replication system in human cells for replicating plasmid-borne adeno-associated virus (AAV) Rep/Cap genes during recombinant AAV (rAAV) production. This new approach not only enables a 10- to 20-fold plasmid reduction to significantly lower manufacturing costs but also substantially enhances rAAV potency, titer, and purity.

Nature, Published online: 07 September 2026; doi:10.1038/s41586-026-11094-2Author Correction: A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution

Nature Biotechnology, Published online: 02 September 2026; doi:10.1038/s41587-026-03294-yDNA recombination in rice is optimized by engineering genomic attachment sites.

Oncogenesis, Published online: 21 August 2026; doi:10.1038/s41389-026-00650-0CD44v5 promotes triple-negative breast cancer cisplatin resistance by enhancing IL-4/IL-4Rα/STAT3 pathway and stabilizing membranous SLC7A11