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Targeting the MNK1-MYH9 axis blocks YAP1 recruitment to prevent thrombosis and platelet activation-induced NETosis

MNK1 acts as a structural shield on MYH9, preventing YAP1-mediated platelet activation. Developing MD2 to lock this MNK1-MYH9 complex introduces a safe antithrombotic strategy, shifting the therapeutic paradigm from kinase inhibition to stabilizing protein-protein interactions against immunothrombosis.

Looped GPT-BERT: Trading Parameters for Computation in Small Language Modeling

arXiv:2609.09691v1 Announce Type: cross Abstract: When training data are limited, increasing parameter count is not the only way to improve language-model performance. A small parameter set, when repeatedly applied, can also deliver comparable performance. We study Looped GPT-BERT in the BabyLM 2026 Strict-small setting, combining GPT-BERT's masked next-token and causal language-modeling objectives with depth-wise parameter sharing. We train on a preprocessed 7.48M-word English corpus and compare objective ratios, non-looped and looped architectures, and loop counts. Our final $4\times12$ model uses four physical layers for twelve recurrent traversals and contains 12.18M parameters. The BabyLM 2026 leaderboard reports an Overall Average of 35.42 and an NLP Average of 48.48. Compared with public BabyLM 10M Strict-small GPT-2 and GPT-BERT baselines, it achieves comparable performance on selected linguistic and downstream metrics, including BLiMP and GLUE, with fewer parameters. The loop ablations show that additional recurrent computation can improve training and preserve strong performance on selected linguistic tasks, whereas poorer performance on other tasks may reveal an inherent limitation of the looped design: using only a few physical layers restricts the model's representational space.
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