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Synchronized latency reversal and immune clearance by a multifunctional fusion protein enables HIV-1 reservoir reduction

Latent HIV reservoirs evade both antiviral therapy and immune surveillance. Luo and colleagues develop a multifunctional fusion protein that couples reservoir reactivation with targeted immune engagement and clearance, offering a coordinated strategy to expose and eliminate persistent HIV-infected cells.

Agent-Based ML-LLM Fusion with Self-Optimizing Prompts for Plateau Weather Alerts

10 September 2026 at 12:00
arXiv:2609.10135v1 Announce Type: new Abstract: To address insufficient contextualization, weak generalization, and poor scenario adaptation in tourism meteorological services, we propose SmartWeatherAgent--a unified three-stage architecture integrating intent recognition, hazard prediction, and reasoning-enhanced generation. The system fuses rule-based methods with large language models to parse queries at multiple granularities and employs a LightGBM model enriched with highland-specific features (e.g., wind speed abruptness rate), achieving an F1-Macro score of 0.605 with 1.60 ms latency on high-wind, precipitation, and low-temperature events. A 12-round micro-step prompt self-optimization loop boosts the composite warning quality score S_final from 4.2 (B01) to 8.9 (B12, +112%). Key improvements include a sharp rise in B08 from data source citation (6.5 -> 8.5), sustained high performance in B10 via physical mechanism explanation, and a peak scientific rigor score of 9.2 in B12 through explicit uncertainty statements. The system autonomously generates structured warnings that integrate causal mechanisms, spatiotemporal evolution, quantitative evidence, regulatory references, and confidence statements--enhancing professional depth, logical rigor, and scientific soundness, and advancing meteorological services toward proactive perception, explainable decision-making, and intelligent agency.

Local lactate-driven H3K18 lactylation impairs anti-influenza immunity through NRF2-dependent dendritic cell dysfunction

Cell Rep. 2026 Sep 3;45(9):117943. doi: 10.1016/j.celrep.2026.117943. Online ahead of print.

ABSTRACT

Metabolic alterations are increasingly recognized during influenza virus infection, but how local lactate accumulation shapes antiviral immunity remains poorly characterized. By integrating time-series targeted energy metabolomics, single-cell RNA sequencing, flow cytometry, and functional perturbation, we show that influenza virus infection preferentially increases lactate within the lung microenvironment, where it restrains pulmonary CD8+ T cell response. Mechanistically, extracellular lactate enters dendritic cells through monocarboxylate transporter (MCT)-dependent transport and induces a tolerogenic-like state marked by impaired maturation, reduced costimulation, and diminished CD8+ T cell-priming capacity. Direct experimental evidence identifies H3K18la as a prominent lactate-responsive histone lactylation mark, while multi-omics integration links it to enhancer accessibility and NRF2 pathway activation. Functional studies further show that NRF2 promotes dendritic cell suppression by reinforcing tolerogenic programs and limiting mtROS-dependent XBP1 splicing. Together, these findings reveal a lactate-driven histone lactylation-NRF2 pathway that modulates antiviral immunity during influenza infection.

PMID:42690934 | DOI:10.1016/j.celrep.2026.117943

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