Normal view
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Molecular Therapy
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Synchronized latency reversal and immune clearance by a multifunctional fusion protein enables HIV-1 reservoir reduction
Latent HIV reservoirs evade both antiviral therapy and immune surveillance. Luo and colleagues develop a multifunctional fusion protein that couples reservoir reactivation with targeted immune engagement and clearance, offering a coordinated strategy to expose and eliminate persistent HIV-infected cells.
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cs.AI, q-bio.NC updates on arXiv.org
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Agent-Based ML-LLM Fusion with Self-Optimizing Prompts for Plateau Weather Alerts
arXiv:2609.10135v1 Announce Type: new Abstract: To address insufficient contextualization, weak generalization, and poor scenario adaptation in tourism meteorological services, we propose SmartWeatherAgent--a unified three-stage architecture integrating intent recognition, hazard prediction, and reasoning-enhanced generation. The system fuses rule-based methods with large language models to parse queries at multiple granularities and employs a LightGBM model enriched with highland-specific feat
Agent-Based ML-LLM Fusion with Self-Optimizing Prompts for Plateau Weather Alerts
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Omics In Lung
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Local lactate-driven H3K18 lactylation impairs anti-influenza immunity through NRF2-dependent dendritic cell dysfunction
Cell Rep. 2026 Sep 3;45(9):117943. doi: 10.1016/j.celrep.2026.117943. Online ahead of print.ABSTRACTMetabolic alterations are increasingly recognized during influenza virus infection, but how local lactate accumulation shapes antiviral immunity remains poorly characterized. By integrating time-series targeted energy metabolomics, single-cell RNA sequencing, flow cytometry, and functional perturbation, we show that influenza virus infection preferentially increases lactate within the lung microen
Local lactate-driven H3K18 lactylation impairs anti-influenza immunity through NRF2-dependent dendritic cell dysfunction
Cell Rep. 2026 Sep 3;45(9):117943. doi: 10.1016/j.celrep.2026.117943. Online ahead of print.
ABSTRACT
Metabolic alterations are increasingly recognized during influenza virus infection, but how local lactate accumulation shapes antiviral immunity remains poorly characterized. By integrating time-series targeted energy metabolomics, single-cell RNA sequencing, flow cytometry, and functional perturbation, we show that influenza virus infection preferentially increases lactate within the lung microenvironment, where it restrains pulmonary CD8+ T cell response. Mechanistically, extracellular lactate enters dendritic cells through monocarboxylate transporter (MCT)-dependent transport and induces a tolerogenic-like state marked by impaired maturation, reduced costimulation, and diminished CD8+ T cell-priming capacity. Direct experimental evidence identifies H3K18la as a prominent lactate-responsive histone lactylation mark, while multi-omics integration links it to enhancer accessibility and NRF2 pathway activation. Functional studies further show that NRF2 promotes dendritic cell suppression by reinforcing tolerogenic programs and limiting mtROS-dependent XBP1 splicing. Together, these findings reveal a lactate-driven histone lactylation-NRF2 pathway that modulates antiviral immunity during influenza infection.
PMID:42690934 | DOI:10.1016/j.celrep.2026.117943