arXiv:2609.12394v1 Announce Type: new Abstract: Mobile GUI agents are shifting from multi-module frameworks to native models trained end-to-end, yet industrial deployment faces three persistent gaps. Sandbox training produces a distribution mismatch with production environments; expensive real-device failures remain underutilized; and fixed benchmarks saturate, losing the power to guide iteration. We present BlueLM-GUI, a 35B-A3B mobile GUI agent built as a real-device-centric flywheel that closes these gaps through three principles. Every Sample Matters: a dual-track pipeline with Heterogeneous Triple-System Consensus evaluation and an Error Correction \& Derivation Module salvages every trajectory into usable supervision. Every Rollout Is Real: a three-stage recipe---continual pre-training, supervised fine-tuning, and agentic reinforcement learning on hundreds of real phones---grounds every rollout in real production environments, so the capability the model learns transfers directly to deployment. Every Query Evolves: a quota-driven benchmark methodology with three orthogonal axes enables precise attribution and allows the benchmark to be systematically upgraded as the model improves. BlueLM-GUI achieves 87.4 on MobileGUI-VBench, surpassing the best closed-source model by 5.1 points, and 84.9 on AndroidWorld, the best result among open-source models and competitive with closed-source models. These results demonstrate that grounding model training and iterative improvement in both real devices and the three Every principles yields strong, robust, and transferable mobile GUI capability.

arXiv:2609.12097v1 Announce Type: cross Abstract: In bespoke art commissions, laypeople know what they feel but lack the words to specify it: one participant wanted a laid-off truck driver depicted as "a ghost in his own machine" but left the medium, scale, and palette unsaid. We frame this as an articulation bottleneck at an under-served upstream stage: requirement discovery, which precedes any artist or image generator and forces the commissioner to constitute intent in the first place. We present MAIA (Multi-Agent Intent Articulation), a multi-agent system that scaffolds this stage through Socratic inquiry under a "Verification over Invention" rule, turning vague affect into a text-only brief of visual terms the user verifies. In a within-subjects study (N = 16), the full configuration produced a large, significant gain in Cognitive Support over a minimal baseline (r = 0.96, p_FDR = 0.015; LMM p_FDR

arXiv:2609.12978v1 Announce Type: cross Abstract: Mixture-of-Experts (MoE) creates a structural advantage for offloading: only a small fraction of activated experts need to reside in device memory, and if they can be loaded in time for computation, offloading can in principle approach full-load performance, where all model weights reside in device memory. Yet translating MoE's structural advantage into practical offloading gains remains challenging. We propose SeqMoE to bridge this gap. To maximize expert hits, we build predictive memory management: (i) Sequence-to-sequence prediction. We are the first to recast expert activation prediction as sequence modeling, enabling accurate multi-step, multi-layer forecasts that provide a long and reliable window for downstream decisions. (ii) Joint prefetch scheduling. We formulate prefetch scheduling as Job Sequencing with Deadlines to maximize expected expert hits and improve bandwidth efficiency. (iii) Forecast-driven caching. Leveraging the recursive nature of sequence modeling, we introduce a probabilistic Belady policy for future-aware eviction. To eliminate execution bottleneck, we develop (iv) Graph-compatible offloading runtime. We derive general runtime principles encompassing compute-transparent expert placement and synchronization-free orchestration disciplines for end-to-end graph capture. With 45% expert residency, SeqMoE averages a 96.97% hit rate and 80.22% of full-load performance, advancing the state of the art in MoE offloading.

Nature Cancer, Published online: 11 September 2026; doi:10.1038/s43018-026-01236-w

Zheng et al. describe how hypoxia-induced methylmalonate semialdehyde dehydrogenase lactylation promotes acyl-CoA synthetase long-chain family member 4 propionylation and degradation, thereby suppressing ferroptosis induced by chemotherapy, and develop a blocking peptide that increased chemotherapy efficacy in pancreatic ductal adenocarcinoma.