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NSUN2 promotes leukemogenesis by ferritin heavy chain 1-mediated anti-ferroptosis and enhancing global protein synthesis in an m5C-dependent manner in B-acute lymphoblastic leukemia

Most Recent Articles: Clinical Epigenetics

By: Yigang Yuan · Min Li · Xuanyu Yu · Chen Meng · Shirui Yu · Xinyao Chen · Shixin Zhang · Liuzhi Shi · Xiaoyi Qin · Ziyang Huang · Chongyun Xing · Shanhu Qian · Bin Zhou and Shenmeng Gao

28 October 2025 at 08:00

NOP2/Sun RNA methyltransferase family member 2 (NSUN2) catalyzes 5-methylcytosine (m5C) modifications in tRNA, rRNA, and mRNA, playing critical roles in various malignancies. However, its expression and functiona...

Role of vascular smooth muscle phenotypic transformation induced by histone modifications in the development of abdominal aortic aneurysms

Most Recent Articles: Clinical Epigenetics

By: Zihao Chen · Yunping Sun · Peng Zhu · Le Zhang · Jian Yang and Jing Zhang

28 October 2025 at 08:00

Abdominal aortic aneurysm (AAA) is a progressive vascular disorder closely associated with the phenotypic transformation of vascular smooth muscle cells (VSMCs). Histone modifications—including acetylation, me...