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Myeloperoxidase inhibition with mitiperstat in heart failure with preserved or mildly reduced ejection fraction: a randomized phase 2b trial

✇Nature Medicine
By: Lars H. Lund · Carolyn S. P. Lam · Patricia Ely Pizzato · Erik Michaëlsson · Andrea Mattsson · Hans Ericsson · Malin Aurell · Anna Collen · Monika Trebski · Carl Whatling · Niklas Bergh · Andrea L. Vavere · Robin Johannes Gerardus Hartman · Alain Cohen-Solal · Chern-En Chiang · Grzegorz Drelich · Assen Goudev · Martin Hudec · Stefan Janssens · Jose Francisco Kerr Saraiva · Lars Køber · Bela Merkely · Lisa Mielniczuk · Ondrej Toman · Sandra Sanders-van Wijk · Stephan Baldus · Sanjiv J. Shah

Nature Medicine, Published online: 09 September 2026; doi:10.1038/s41591-026-04615-z

In a phase 2 randomized clinical trial, treatment with the myeloperoxidase (MPO) inhibitor mitiperstat, intended to target the neutrophil–MPO inflammatory pathway, did not improve symptoms or exercise function in individuals with heart failure with preserved or mildly reduced ejection fraction.
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Flexible ensheathment of axons enables myelination of complex CNS networks

✇Nature - Issue - nature.com science feeds
By: Cody L. Call · Sarah A. Neely · Jason J. Early · Owen G. James · Lida Zoupi · Anna C. Williams · Yu Kang T. Xu · Siddharthan Chandran · David A. Lyons · Kelly R. Monk · Dwight E. Bergles

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10312-1

The rate of axon ensheathment varies within individual myelinating processes, resulting in chains of myelin sheaths connected by bridges consisting of thin cytoplasmic processes that provide flexibility for myelination of highly branched axons.
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Author Correction: Phenome-wide analysis of copy number variants in 470,727 UK Biobank genomes

✇Nature - Issue - nature.com science feeds
By: Xueqing Zoe Zou · Fengyuan Hu · Haiyi Lou · Oliver S. Burren · Xiaoyin Li · Karyn Megy · Eleanor Wheeler · Qiang Wu · Santosh S. Atanur · Marcin Karpinski · Douglas Loesch · Zammy Fairhurst-Hunter · Sri V. V. Deevi · Erin Oerton · Sean Wen · Xiao Jiang · Cecilia Salvoro · Jonathan Mitchell · Abhishek Nag · Ben Hollis · Amanda O’Neill · Lauren Anderson-Dring · Mohammad Bohlooly-Y · Lisa Buvall · Sophia Cameron-Christie · Bram Prins · Suzanne Cohen · Regina F. Danielson · Andrew Davis · Wei Ding · Brian Dougherty · Manik Garg · Benjamin Georgi · Andrew Harper · Carolina Haefliger · Mårten Hammar · Richard N. Hanna · Ian Henry · Kousik Kundu · Zhongwu Lai · Mark Lal · Glenda Lassi · Yupu Liang · Margarida Lopes · Kieren Lythgow · Meeta Maisuria-Armer · Ruth March · Dorota Matelska · Rob Menzies · Erik Michaëlsson · Bill Mowrey · Daniel Muthas · Yoichiro Ohne · Benjamin Pullman · Sonja Hess · Arwa Raies · Anna Reznichenko · Xavier Romero Ros · Helen Stevens · Ioanna Tachmazidou · Coralie Viollet · Dimitrios Vitsios · Anna Walentinsson · Lily Wang · Qing-Dong Wang · Anna C

Nature, Published online: 31 March 2026; doi:10.1038/s41586-026-10389-8

Author Correction: Phenome-wide analysis of copy number variants in 470,727 UK Biobank genomes
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