❌

Reading view

Fibronectin 1 mediated histone lactylation promotes malignant progression of GIST regulated by m<sup>6</sup>A modification

Cell Death Discovery nature.com science feeds

By: Ge Zhang · Jiehan Li · Yuhan Yin · Wunan Mi · Hao Liu · Zhao Sun · Jiahao Liu · Yizheng Zhang · Meimei Jiang · Nannan Liu · Guiyun Jia · Yingjie Zhang · Yang Fu

11 September 2026 at 08:00

Cell Death Discovery, Published online: 11 September 2026; doi:10.1038/s41420-026-03338-x

Fibronectin 1 mediated histone lactylation promotes malignant progression of GIST regulated by m⁶A modification

CRTAM inhibition mitigates toxicity of immune checkpoint inhibitors without antitumor efficacy trade-off

Nature Cancer

By: Si-Cong Ma · Zi-Xuan Rong · Zi-Peng Xu · Yan-Pei Zhang · Kui-Mao Zhuang · Hao Sun · Chuan-Hui Cao · Ze-Nan Wu · Hai-Peng Zhang · Qiang Zuo · Jia-Run Lin · Jia-Xin Cheng · Hua-Ting Qu · Duan-Duan Han · Wei Wei · Ke Liu · Xiao-Ting Cai · Ze-Qin Guo · Xue Bai · Li Liu · De-Hua Wu · Zhong-Yi Dong

5 March 2026 at 08:00

Nature Cancer, Published online: 05 March 2026; doi:10.1038/s43018-026-01135-0

Dong and colleagues report that blockade of T cell-expressed cytotoxic and regulatory T cell molecule results in selective mitigation of immune-related toxicities without affecting antitumor efficacy of immune checkpoint inhibitors.