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Propionyl-CoA catabolism is a metabolic gatekeeper for fatty acid oxidation in pancreatic cancer

Oncogene - Issue - nature.com science feeds

By: Weidong Yu · Bo Wang · Fanhao Meng · Xiaojun Ren · Danyi Zhou · Huanxin Wei · Zhengquan Yang · Hongwei Sun · Minghua Jiang · Tao Xia · Wei Cui · Hezhi Fang

11 September 2026 at 08:00

Oncogene, Published online: 11 September 2026; doi:10.1038/s41388-026-03979-3

Propionyl-CoA catabolism is a metabolic gatekeeper for fatty acid oxidation in pancreatic cancer

Facile induction of immune tolerance by an interleukin-2–TGFβ surrogate agonist

Nature - Issue - nature.com science feeds

By: Qinli Sun · Alison K. Barrett · Masato Ogishi · Huiyun Lyu · Hua Jiang · Honghui Liu · Yang Zhao · Grayson E. Rodriguez · Pingdong Tao · Matthias Obenaus · Karsten D. Householder · Qizhi Tang · Tobias V. Lanz · K. Christopher Garcia

11 March 2026 at 08:00

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10208-0

A fusion protein designed to comprise IL-2 and a helminth-derived TGFβ mimic activates IL-2 and TGFβ signalling pathways in IL-2 receptor-expressing T cells and induces stable antigen-specific regulatory T cells in peripheral lymphoid organs.