Factor IX Padua AAV gene therapy in adolescents with hemophilia B: a phase 1 trial

By: Feng Xue · Ai Zhang · Mankai Ju · Xia Wu · Bingqi Xu · Xiaolei Pei · Yuhua Wang · Wei Liu · Aiguo Liu · Wei Jiang · Xinyue Dai · Yunfei Chen · Xiaofan Liu · Rongfeng Fu · Ting Sun · Wenjing Gu · Jing Zheng · Zengmin Du · Caifeng Yang · Xiao Xiao · Renchi Yang · Qun Hu · Lei Zhang

16 September 2026 at 08:00

Nature Medicine, Published online: 16 September 2026; doi:10.1038/s41591-026-04636-8

In this single-arm phase 1 trial, an AAV gene therapy carrying the Padua variant of factor IX was well tolerated in 11 adolescents with hemophilia B and led to reductions in annualized bleeding rate.

Hypoxia-induced XBP1s-MYDGF axis suppresses ferroptosis through UBQLN1-mediated stabilization of LCN2 in gastric cancer

Oncogene - Issue - nature.com science feeds

By: Qi Zhou · Hongyan Qi · Yonghui Zou · Zhenqi Yue · Jinheng Gan · Hesong Xu · Luojun Fan · Hua Wan · Lin Xin

7 April 2026 at 08:00

Oncogene, Published online: 07 April 2026; doi:10.1038/s41388-026-03760-6

Hypoxia-induced XBP1s-MYDGF axis suppresses ferroptosis through UBQLN1-mediated stabilization of LCN2 in gastric cancer

Unified modeling of 3D molecular generation via atomic interactions with PocketXMol

Cell

By: Xingang Peng · Ruihan Guo · Fenglin Guo · Ziyi Wang · Jiayu Sun · Jiaqi Guan · Yinjun Jia · Yan Xu · Yanwen Huang · Muhan Zhang · Jian Peng · Xinquan Wang · Chuanhui Han · Zihua Wang · Jianzhu Ma

18 February 2026 at 08:00

A versatile, atom-level generative AI model enables unified pocket-interacting tasks, from docking to de novo design, and demonstrates robust experimental validation for both small-molecule and peptide therapeutics.