Oncogene, Published online: 18 April 2026; doi:10.1038/s41388-026-03797-7

Granzyme B-based CAR-T cells targeting membrane-bound HSP70 suppress solid tumor growth and metastasis

In a preclinical breast cancer metastasis model, the same bacteria strain, when present intracellularly versus extracellularly, exerts opposing effects on tumor immunity by inducing divergent neutrophil states, highlighting the intricacy in bacterial-host engagement for shaping tumor immunity.