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MUC13 promotes cisplatin resistance in intrahepatic cholangiocarcinoma through regulation by histone H3K18 lactylation

Cell Death Discovery, Published online: 01 September 2026; doi:10.1038/s41420-026-03324-3

MUC13 promotes cisplatin resistance in intrahepatic cholangiocarcinoma through regulation by histone H3K18 lactylation
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Targeting peripheral 5-HT2AR enhances antitumor immunity in colorectal cancer

By selectively targeting peripheral 5-HT2AR without inducing psychedelic effects, a non-brain-penetrant agonist boosts antitumor CD8+ T cell immunity and improves immunotherapy responses in preclinical models of colorectal cancer.
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Mummified early Permian reptile reveals ancient amniote breathing apparatus

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10307-y

A mummified fossil of the early Permian reptile Captorhinus reveals the potential ancestral amniote breathing mechanism and its impact on terrestrial vertebrate evolution.
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SRSF10 promotes cisplatin resistance in bladder cancer via BIN1 Exon 12 retention and ANXA1 activation

Oncogene, Published online: 06 April 2026; doi:10.1038/s41388-026-03735-7

SRSF10 promotes cisplatin resistance in bladder cancer via BIN1 Exon 12 retention and ANXA1 activation
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