Liu et al. develop Oncoformer, a multimodal transformer that reads routine laboratory tests and chest X-rays already collected in everyday care. Across more than 3.6 million individuals, it detects cancer, infers tumor stage, and stratifies treatment response and recurrence risk, pointing toward risk-adapted cancer care built on data already in hand.

Within the skin, glutamatergic neurons expressing neurofilament heavy chain (Nefh) play a role in aging. Loss of Nefh during aging drives skin fibroblast senescence and collagen loss, whereas glutamate supplementation improves skin aging phenotypes.

Nature, Published online: 21 May 2026; doi:10.1038/s41586-026-10656-8

De novo design of miniproteins targeting GPCRs

Oncogene, Published online: 21 May 2026; doi:10.1038/s41388-026-03819-4

circPARPBP promotes cancer stemness and chemoresistance in triple-negative breast cancer through recruiting SRCAP complex to activate CCL20 transcription

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10342-9

A clinical phase 1 trial of a single infusion of CS-101, CD34+ cells modified using a transformer base editor to reactivate fetal haemoglobin production, led to early and enduring transfusion independence in patients with β-thalassaemia.

npj Digital Medicine, Published online: 02 April 2026; doi:10.1038/s41746-026-02572-y

Integrating large language models for enhanced predictive analytics in healthcare

Nature, Published online: 31 March 2026; doi:10.1038/s41586-026-10442-6

Structure of the mouse cytoplasmic lattice