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Disruption of the AR/ZNF217/PROM2 axis sensitizes prostate cancer to ferroptosis and enzalutamide therapy

Oncogenesis, Published online: 11 August 2026; doi:10.1038/s41389-026-00649-7

Disruption of the AR/ZNF217/PROM2 axis sensitizes prostate cancer to ferroptosis and enzalutamide therapy
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Activation of methionine metabolism mediated by HNF4α confers ferroptosis resistance in hepatocellular carcinoma

Cell Death Discovery, Published online: 26 May 2026; doi:10.1038/s41420-026-03165-0

Activation of methionine metabolism mediated by HNF4α confers ferroptosis resistance in hepatocellular carcinoma
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High-fidelity identification of guest species in porous materials

Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10527-2

A reconstruction method based on Gaussian-apodized single-sideband electron ptychography removes artefacts to enable the high-fidelity identification of guest species in porous materials.
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Cell-type-specific transposon demethylation and TAD remodeling in aging mouse brain

A multi-omic single-cell atlas of the aging mouse brain reveals cell-type-specific transposon methylation changes, strengthening of 3D genome boundaries, and regionally heterogeneous aging signatures. These findings offer a resource to understand the molecular mechanisms of brain aging and guide future research on neurodegeneration.
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