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Disruption of the AR/ZNF217/PROM2 axis sensitizes prostate cancer to ferroptosis and enzalutamide therapy

Oncogenesis, Published online: 11 August 2026; doi:10.1038/s41389-026-00649-7

Disruption of the AR/ZNF217/PROM2 axis sensitizes prostate cancer to ferroptosis and enzalutamide therapy
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A pathogen lncRNA secreted into rice sequesters a host miRNA for virulence

Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10572-x

A fungal long non-coding RNA from Magnaporthe oryzae translocates into rice cells to sequester a host microRNA that normally represses PKR1, a negative immunity regulator, thereby facilitating infection and revealing a widespread RNA-based pathogen–host interaction mechanism.
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Mirror-enhanced 4Pi-SMLM with one objective enables isotropic nanoscale imaging

Nature Biotechnology, Published online: 31 March 2026; doi:10.1038/s41587-026-03083-7

Single-molecule 4Pi microscopy is simplified and made accessible by using a single objective.
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A functional map of m<sup>6</sup>A sites in cancer

Nature Cancer, Published online: 13 March 2026; doi:10.1038/s43018-026-01137-y

RNA N6-methyladenosine (m6A) is the most abundant internal RNA modification, yet its functional landscape in cancer remains poorly defined. A study now introduces a METTL3-based RNA base-editing screen that maps functional m6A sites and reveals m6A-dependent translational activation of the tumor suppressor CHD9 in prostate cancer and beyond.
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