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Combined ctDNA and serum PSA for dynamic monitoring of metastatic prostate cancer starting first-line treatment: a prospective national cohort study

Nature Cancer, Published online: 15 May 2026; doi:10.1038/s43018-026-01172-9

Jayaram et al. assessed the performance of the combination of circulating tumor DNA and serum prostate-specific antigen for dynamic monitoring of metastatic prostate cancer at first-line treatment in this prospective observational clinical trial.
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Mitochondrial control of glycerolipid synthesis by a PEP shuttle

SLC25A35 is revealed as the mitochondrial PEP exporter that licenses glycerolipid synthesis in lipogenic cells, linking mitochondrial energetics to lipid production. Mitochondrial PEP flux drives glycerol-3-phosphate and triglyceride synthesis, and blocking SLC25A35 reduces hepatic steatosis, offering a target for metabolic therapy.
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