npj Digital Medicine, Published online: 14 September 2026; doi:10.1038/s41746-026-03225-w

Data-driven identification of repurposable drugs for ALS

Nature Medicine, Published online: 14 September 2026; doi:10.1038/s41591-026-04639-5

Trust in clinical artificial intelligence (AI) cannot be benchmarked into existence. It must be earned through rigorous prospective studies in real-world clinical settings, where the hardest lessons often concern the humans and systems around the AI, not the technology itself.

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10954-1

A specific population of macrophages that express high levels of the enzyme PLA2G2D in tumour-draining lymph nodes is associated with poor prognosis in patients, and inhibiting PLA2G2D improves anti-tumour immunity in mouse models.

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10968-9

Deep-foam photolithography uses light-controlled polymer foaming to create high-resolution, multifunctional microstructures with tunable optical, wetting and fluid-handling properties for advanced manufacturing applications.

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11004-6

Integrating satellite-derived war-damage data with text-based fatality records through improvement, enrichment and fusion mitigates limitations inherent in each source, revealing complex violence dynamics beyond fatality-centric paradigms, as case studies from Ukraine and Myanmar illustrate.

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10979-6

An imaging system developed to record cellular activity throughout the whole body of zebrafish captures cellular organ dynamics and identifies multiple distributed circuits.

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11003-7

A proximity-mapping atlas defines tumour-associated proximity antigens, revealing disease-associated membrane spatial communities, and identifies EGFR–CDCP1 as a co-target pair that enhances tumour killing by multispecific therapeutics.

Nature Biotechnology, Published online: 07 September 2026; doi:10.1038/s41587-026-03286-y

Six proteomic clocks are applied in a clinical trial to assess anti-aging effects.

Cell Death Discovery, Published online: 03 September 2026; doi:10.1038/s41420-026-03327-0

Arrest of human spermatogenesis at the pachytene stage is frequently accompanied by disruption of the piRNA pathway

Nature, Published online: 26 May 2026; doi:10.1038/s41586-026-10651-z

Author Correction: In vitro characterization of the human segmentation clock

Nature, Published online: 19 May 2026; doi:10.1038/d41586-026-01605-6

AI might jeopardize the uncertainty required in science

Multiomics profiling of healthy individuals reveals differences across molecular layers and key pathways related to immune, metabolic, and microbiome-linked processes across ethnicities, while geographic relocation reshapes these networks and influences aging trajectories.

An optogenetic model of accelerated intermittent theta burst stimulation reveals cell type-specific plasticity mechanisms and a key role for a fronto-insular circuit in driving the antidepressant effects of this treatment in humans.

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10368-z

The E3 ligase SCFFBXO42 degrades holoenzyme-free PP2Ac in complex with the coiled-coil protein CCDC6 to maintain cancer cell fitness

Whole-brain tissue clearing and spatial transcriptomics were applied to map postnatal vascular development in the mouse brain, identifying three coordinated phases that link vascular growth to neuronal maturation.

A platform called MIST enables quantification and genotyping of infectious influenza in expelled respiratory particles, revealing diverse, individual-specific viral loads and aerosolized variants that correlate with saliva and nasopharyngeal viral loads and symptoms. Overall, the findings indicate heterogeneity in transmission potential.

Background: The World Health Organization recommends that countries routinely collect data on the behavioral and social drivers (BeSD) of vaccination to inform public health interventions that increase vaccine uptake. There is a need to identify data collection methods that can rapidly and inexpensively collect representative data, particularly in low- and middle-income countries. Objective: This study aimed to understand BeSD drivers of vaccination in the Philippines and assess the trade-offs between survey methods. We compared responses to household, mobile, and online surveys in terms of demographics, vaccination status, responses to BeSD questions, and cost. Methods: We conducted concurrent household, mobile (SMS text messaging and interactive voice response), and online surveys among caregivers of children 2 years of age and below in Regions V and XII of the Philippines, with sampling differing by survey method. We assessed, for each survey method, (1) respondent demographics (sex, age, region, and socioeconomic status) and (2) the weighted proportion of responses from caregivers of children who received at least one dose of diphtheria-pertussis-tetanus (DPT)–containing vaccine. We estimated the weighted proportion of each BeSD survey response option and calculated the financial cost (monetary outlays) per survey response from an implementer’s perspective by summing the costs incurred in each survey method and dividing by the number of responses received. Results: We surveyed a total of 1201 household respondents, 2153 mobile respondents, and 398 online respondents from January to March 2025. We found that online and mobile survey respondents were more likely to be male and have completed high school than household survey respondents. The weighted proportion of respondents indicating that their child had received at least one dose of DPT vaccine was 91.8% (n=1090; 95% CI 90%‐93.3%) for the household survey, 90.3% (n=1853) for the mobile survey, and 85% (n=346) for the online survey. With regard to vaccine demand, more than 85% of respondents in each survey method indicated that vaccines are very important, very safe, supported by family, and that they knew where to bring a child for vaccination. More than 30% of mobile and online survey respondents indicated that it was not easy to pay for vaccination. The financial cost to conduct the survey per survey response was US $2.61 for the online survey, US $6.93 for the mobile survey, and US $29.38 for the household survey. Conclusions: In the Philippines, household, mobile, and online survey methods reached caregivers of children who were unvaccinated against DPT, and these proportions were similar across survey methods. BeSD responses indicated high vaccine demand and challenges in caregivers’ cost to access vaccination. Determining the most appropriate survey method depends on trade-offs between representativeness and costs. However, areas with strong connectivity and high mobile device ownership can consider mobile and online methods as a lower-cost alternative to rapidly collect BeSD data.

Nature, Published online: 10 April 2026; doi:10.1038/s41586-026-10484-w

Author Correction: Multi-omic profiling reveals age-related immune dynamics in healthy adults

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10168-5

The CMS experiment at CERN reports one of the highest-precision measurements of the W boson mass, finding it in line with standard model predictions and at odds with recent anomalous measurements.

Nature, Published online: 08 April 2026; doi:10.1038/d41586-026-00630-9

The latest value for the mass of a fundamental particle called the W boson is consistent with the standard model of particle physics, challenging a previous anomalous result.