Nature Biotechnology, Published online: 26 May 2026; doi:10.1038/s41587-026-03153-w

Building a living cell from scratch requires overcoming a bottleneck that has remained unresolved despite decades of progress: orchestrating the spatiotemporal integration of core functional modules. To tackle this barrier, the SynCell Asia Initiative outlines a strategy for developing core functional modules followed by their systems-level integration through the establishment of a centralized, artificial intelligence (AI)-driven biofoundry.

Cell Death Discovery, Published online: 25 May 2026; doi:10.1038/s41420-026-03128-5

Deubiquitinase USP35 regulates MDM4 degradation to promote endothelial ferroptosis and renal injury progression

Oncogene, Published online: 09 April 2026; doi:10.1038/s41388-026-03775-z

Plasmin promotes hepatocellular carcinoma invasion and metastasis via CXCR4-mediated activation of PI3K/AKT/mTOR signaling

Oncogene, Published online: 06 April 2026; doi:10.1038/s41388-026-03735-7

SRSF10 promotes cisplatin resistance in bladder cancer via BIN1 Exon 12 retention and ANXA1 activation

npj Digital Medicine, Published online: 24 March 2026; doi:10.1038/s41746-026-02560-2

Boosting foundation models for rare eye disease diagnosis via a multimodal text-to-image generative framework