Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11002-8

SERPINE1 and SERPINB2-driven fibrin-rich niches locally programme immunosuppressive macrophages and exclude T cells, enabling spatially organized immune evasion in pancreatic ductal carcinoma.

Nature Cancer, Published online: 22 May 2026; doi:10.1038/s43018-026-01167-6

Ahmed and colleagues show that, by promoting ‘dressing’ of intact tumor target antigens onto dendritic cells, tumor irradiation enhances chimeric antigen receptor T cell persistence and efficacy in lung metastasis models.