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Template-driven scaffolding of SCF<sup>FBXO42</sup> regulates PP2A degradation

βœ‡Nature - Issue - nature.com science feeds
By: Sebastien Coassolo Β· Nairie Michaelian Β· Timurs Maculins Β· Caleigh M. Azumaya Β· Tommy K. Cheung Β· Jianping Yin Β· Inna Zilberleyb Β· Kanika Bajaj Pahuja Β· Thomas Garner Β· Ted Lau Β· Davis Mau Β· Matthew Grimmer Β· Jean-Philippe Fortin Β· Mike Costa Β· Yoana N. Dimitrova Β· Christopher M. Rose Β· Peter L. Hsu Β· Robert L. Yauch

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10368-z

The E3 ligase SCFFBXO42 degrades holoenzyme-free PP2Ac in complex with the coiled-coil protein CCDC6 to maintain cancer cell fitness
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