Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10993-8

TM184C—an ancient G-protein-coupled receptor-like superdark protein involved in regulation of autophagy, intercellular connectivity and material exchange—underscores the promise of exploring the understudied human proteome and beyond.

npj Digital Medicine, Published online: 26 May 2026; doi:10.1038/s41746-026-02798-w

Personalized neoadjuvant treatment regimen selection in locally advanced rectal cancer based on regimen-specific response modeling

npj Digital Medicine, Published online: 03 April 2026; doi:10.1038/s41746-026-02557-x

Label-free pathological subtyping of non-small cell lung cancer using deep classification and virtual immunohistochemical staining

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10325-w

Researchers created a moiré superlattice in Sb2Te3/FeTe bilayers, producing spatially modulated superconducting gaps directly imaged with Josephson scanning tunnelling microscopy and spectroscopy, tunable by replacing Sb2Te3 with Bi2Te3.

Background: The rapid digitalization of health care has reshaped access to medical services. However, older adults often remain disadvantaged due to the digital divide. Electronic health literacy (EHL) is increasingly recognized as a determinant of health-related quality of life (HRQoL); however, its mechanisms and subgroup differences in China remain underexplored. Objective: This study aimed to examine the association between EHL and multidimensional HRQoL among Chinese older adults, with a focus on the mediating roles of attitudes toward own aging (ATOA) and self-efficacy (SE), and heterogeneity by age, residence, and lifestyle. Methods: A cross-sectional survey (July-November 2024) included 8364 adults aged ≥55 years from 4 provinces using stratified multistage sampling. HRQoL was measured by physical health (PH), mental health (MH), and life satisfaction (LS). EHL was assessed with the eHealth Literacy Scale (eHEALS), ATOA with the Philadelphia Geriatric Center Morale Scale subscale, and SE with the General Self-Efficacy Scale. Analyses used seemingly unrelated regressions, PROCESS (Andrew F. Hayes) macro mediation with 5000 bootstraps, and subgroup regressions. Results: EHL was positively associated with PH (=0.273;