Nature Cancer, Published online: 03 April 2026; doi:10.1038/s43018-026-01145-y

Huang, Hou, Yang et al. demonstrate that leptomeningeal metastatic cells favor the formation of a premetastatic niche by remodeling the choroid plexus vasculature through the serotonin metabolite 5-hydroxyindoleacetic acid, which signals into endothelial cells through the aryl hydrocarbon receptor.

Nature Biotechnology, Published online: 01 April 2026; doi:10.1038/s41587-026-03051-1

ERAST speeds up homology search and provides a vector database for 1 billion biological sequences.