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Disruption of the AR/ZNF217/PROM2 axis sensitizes prostate cancer to ferroptosis and enzalutamide therapy

Oncogenesis, Published online: 11 August 2026; doi:10.1038/s41389-026-00649-7

Disruption of the AR/ZNF217/PROM2 axis sensitizes prostate cancer to ferroptosis and enzalutamide therapy
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Ferritin aggregation cell engager for CAR T avidity engineering against refractory leukemias

Li et al. developed a ferritin aggregation cell engager that helps CAR T cells better recognize and attack leukemia cells without re-engineering the CAR itself. This versatile platform overcomes antigen modulation and enables combination with chemotherapy.
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Targeting FTO shows therapeutic potential in esophageal squamous cell carcinoma by modulating microRNA biogenesis

Oncogene, Published online: 01 April 2026; doi:10.1038/s41388-026-03754-4

Targeting FTO shows therapeutic potential in esophageal squamous cell carcinoma by modulating microRNA biogenesis
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<i>KRAS</i>-extrachromosomal DNA drives intratumoral heterogeneity in gastric cancer

Oncogene, Published online: 05 March 2026; doi:10.1038/s41388-026-03713-z

KRAS-extrachromosomal DNA drives intratumoral heterogeneity in gastric cancer
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