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ESAM reduces sensitivity to anti-HER2 therapy in HER2-positive breast cancer by activating the mTOR pathway

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Carbonyl swapping converts cyclic ketones to saturated heterocycles

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Graphicalized vision-language modeling for comprehensive lung nodule analysis and risk stratification

A versatile, atom-level generative AI model enables unified pocket-interacting tasks, from docking to de novo design, and demonstrates robust experimental validation for both small-molecule and peptide therapeutics.