PROM2 axis sensitizes prostate cancer to ferroptosis and enzalutamide therapy

By: Wenjun Hao · Peng Liang · Wanglong Zheng · Minglu Sheng · Yulin Peng · Xiang Gao · Haolin Zhao · Yuyan Zhu · Yanlong Wang · Bo Fan · Zhihong Dai · Xu Sun · Liang Wang · Huan Qi · Ying Wang · Yan Wang · Zhenlong Yu · Zhiyu Liu

11 August 2026 at 08:00

Oncogenesis, Published online: 11 August 2026; doi:10.1038/s41389-026-00649-7

S100A6 promotes liver metastasis by activating FGFR3 signaling in <i>BAP1</i>-deficient uveal melanoma

Oncogene - Issue - nature.com science feeds

By: Yonghao Li · Churun Zheng · Yanting Liang · Yue Liu · Fanfan Zhou · Xue Zhu · Jing Fang · Renhua Gai · Yanyan Zhuang · Ke Wang · Tao Yuan · Qiaojun He · Bo Yang · Xin Dong · Hong Zhu

4 April 2026 at 08:00

Oncogene, Published online: 04 April 2026; doi:10.1038/s41388-026-03766-0

S100A6 promotes liver metastasis by activating FGFR3 signaling in BAP1-deficient uveal melanoma

Excessive pyroptosis mediates the exacerbation of pneumonia caused by low-lethality influenza virus and secondary MRSA co-infection

Cell Death Discovery nature.com science feeds

By: Zi-Chen Tian · Yang Liu · Yi-Jun Niu · Xin Ai · Su-Ya Lao · Wei-Ming Xu · Xiao-Tong Lin · Cheng-Jie Xia · Zhi-Xuan Cai · Hai-Yan Zhu · Xun-Long Shi

2 April 2026 at 08:00

Cell Death Discovery, Published online: 02 April 2026; doi:10.1038/s41420-026-03031-z

Excessive pyroptosis mediates the exacerbation of pneumonia caused by low-lethality influenza virus and secondary MRSA co-infection

Metabolite-gated vascular contractility switch: OXGR1 activation mechanism enables agonist therapy for rosacea erythema

Cell

By: Wenqin Xiao · Yan Zhu · Xinjie Tang · Kongkai Zhu · Weifeng Zhang · Mengting Chen · Kui Cai · San Xu · Zheng Wu · Mei Wang · Jiayi Liu · Linglong Long · Zixin Tan · Aike Wu · Songqi Zhou · Zhixiang Zhao · Yan Tang · Yingxue Huang · Ben Wang · Fangfen Liu · Qian Wang · Fan Yang · Dan Jian · Wei Shi · Hongfu Xie · Xiang Chen · Lulu Guo · Zhili Deng · Jinpeng Sun · Ji Li

5 March 2026 at 08:00

Xiao et al. identify α-KG as a rosacea-associated metabolite that activates the OXGR1-Gq-MYL9 axis in the vascular smooth muscle cells to boost contractility and suppress pathological vasodilation underlying erythema. Cryo-EM reveals a bipartite-acid pocket of OXGR1 that enables structure-guided development of A-1, a selective agonist that alleviates erythema in rosacea-like models.

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