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Facile induction of immune tolerance by an interleukin-2–TGFβ surrogate agonist

Nature - Issue - nature.com science feeds

By: Qinli Sun · Alison K. Barrett · Masato Ogishi · Huiyun Lyu · Hua Jiang · Honghui Liu · Yang Zhao · Grayson E. Rodriguez · Pingdong Tao · Matthias Obenaus · Karsten D. Householder · Qizhi Tang · Tobias V. Lanz · K. Christopher Garcia

11 March 2026 at 08:00

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10208-0

A fusion protein designed to comprise IL-2 and a helminth-derived TGFβ mimic activates IL-2 and TGFβ signalling pathways in IL-2 receptor-expressing T cells and induces stable antigen-specific regulatory T cells in peripheral lymphoid organs.

Lysophosphatidylcholine acyltransferase 1 promotes head and neck squamous cell carcinoma progression by enhancing COX17-dependent oxidative phosphorylation

Cell Death Discovery nature.com science feeds

By: Yuanyang Zhao · Yun Li · Yanshi Li · Zhihai Wang · Chuan Liu · Lin Chen · Min Wang · Mengna Wang · Zhaobo Cheng · Guohua Hu · Min Pan

6 March 2026 at 08:00

Cell Death Discovery, Published online: 06 March 2026; doi:10.1038/s41420-026-02994-3

Lysophosphatidylcholine acyltransferase 1 promotes head and neck squamous cell carcinoma progression by enhancing COX17-dependent oxidative phosphorylation