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ACTB promotes ESCC progression by regulating the AKT–mTOR signaling pathway through an m<sup>6</sup>A-dependent mechanism

Oncogene, Published online: 30 September 2026; doi:10.1038/s41388-026-03995-3

ACTB promotes ESCC progression by regulating the AKT–mTOR signaling pathway through an m6A-dependent mechanism
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Acrolein- thioredoxin 1- p38 signaling drives neutrophil-mediated immunosuppression and glioblastoma progression

Oncogenesis, Published online: 14 September 2026; doi:10.1038/s41389-026-00655-9

Acrolein- thioredoxin 1- p38 signaling drives neutrophil-mediated immunosuppression and glioblastoma progression
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Targeting peripheral 5-HT2AR enhances antitumor immunity in colorectal cancer

By selectively targeting peripheral 5-HT2AR without inducing psychedelic effects, a non-brain-penetrant agonist boosts antitumor CD8+ T cell immunity and improves immunotherapy responses in preclinical models of colorectal cancer.
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