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Lipotoxicity-induced ER-mitochondrial hypercoupling activates the mtDNA-cGAS-STING-NF-κB axis to drive follicular arrest in metabolically compromised PCOS

Cell Death Discovery nature.com science feeds

By: Mingrui Xue · Qi Zhu · Shuli Zhang · Guangzong Zhao · Xiaoqi Hong · Di Pang · Yue Xu · Xiaolu Li · Yuxin Liu · Ying Li · Qiucheng Jia · Sisi Xu · Hongshan Ge

8 September 2026 at 08:00

Cell Death Discovery, Published online: 08 September 2026; doi:10.1038/s41420-026-03339-w

Lipotoxicity-induced ER-mitochondrial hypercoupling activates the mtDNA-cGAS-STING-NF-κB axis to drive follicular arrest in metabolically compromised PCOS

LUMI-lab: A foundation model-driven autonomous platform enabling discovery of ionizable lipid designs for mRNA delivery

Cell

By: Yue Xu · Haotian Cui · Kuan Pang · Gen Li · Fanglin Gong · Songtao Dong · Bo Wang · Bowen Li

24 February 2026 at 08:00

LUMI lab is a foundation model-driven self-driving platform that autonomously discovers ionizable lipids for mRNA delivery. Iterative active learning uncovered brominated tails as a potent structural motif that enables efficient and safe pulmonary mRNA delivery.