MUC13 promotes cisplatin resistance in intrahepatic cholangiocarcinoma through regulation by histone H3K18 lactylation

Cell Death Discovery nature.com science feeds

By: Zhijie Yin · Qingfu Lang · Jia Sun · Yinfan Wang · Chen Jia · Boxin Chen · Zhen Cui · Ze Wang · Wenjun Chen · Zejun Luo · Ming Yang · Tiemin Pei

1 September 2026 at 08:00

Cell Death Discovery, Published online: 01 September 2026; doi:10.1038/s41420-026-03324-3

MUC13 promotes cisplatin resistance in intrahepatic cholangiocarcinoma through regulation by histone H3K18 lactylation

Activation of methionine metabolism mediated by HNF4α confers ferroptosis resistance in hepatocellular carcinoma

Cell Death Discovery nature.com science feeds

By: Xiaolei Zhou · Zhenzhen Li · Libo Wang · Yongdeng Xu · Pinsheng Han · TianYu Zhao · Sen Liu · Liuyang Zhu · Miao Zhang · Chenglong Chu · Xiulin Yi · Fengying Yan · Tao Cui · Xiaoliang Wang · Ze Wang

26 May 2026 at 08:00

Cell Death Discovery, Published online: 26 May 2026; doi:10.1038/s41420-026-03165-0

Activation of methionine metabolism mediated by HNF4α confers ferroptosis resistance in hepatocellular carcinoma

CD300ld on pathologically activated neutrophils promotes tumor immune suppression by binding phosphatidylserine on CD8<sup>+</sup> T cells

Nature Cancer

By: Chaoxiong Wang · Peixuan Zheng · Anhui Wang · Xinrui Fan · Tianxiang Li · Jingjing Hong · Runze Wang · Chunyan Zhang · Chaogui Luo · Weiwei Yang · Dong Gao · Adili Salai · Min Luo · Zhigang Lu · Dianfan Li · Moubin Lin · Jiayin Peng · Guohui Li · Shuo Han · Yun Zhao

15 May 2026 at 08:00

Nature Cancer, Published online: 15 May 2026; doi:10.1038/s43018-026-01169-4

Zhao and colleagues show that CD300ld, upregulated in pathologically activated neutrophils, mediates contact-dependent suppression of cytotoxic CD8+ T cells by binding to phosphatidylserine, inhibiting antitumor immune responses.

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