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Harnessing pyroptosis in breast cancer therapy: immunological mechanisms and emerging biomaterial strategies
Cell Death Discovery, Published online: 12 March 2026; doi:10.1038/s41420-026-02996-1
Harnessing pyroptosis in breast cancer therapy: immunological mechanisms and emerging biomaterial strategies
A large-scale coherent 4D imaging sensor
Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10183-6
A 4D imaging architecture using a large-scale, coherent LiDAR focal plane array comprising more than 0.6 million photonic components and associated electronics integrated on-chip can obtain coherent images at high frame rates over useful distances.
Multimodal electron microscopy of halide perovskite interfacial dynamics
Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10238-8
A multimodal in situ electron microscopy approach enables direct visualization of structural and chemical evolution in a working halide perovskite light-emitting diode with nanometre precision.
A sorghum pangenome reference improves global crop trait discovery
Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10229-9
A pangenome reference for the phenotypically diverse crop sorghum aims to help accelerate future efforts to breed crops that are better adapted to changing environments.
Author Correction: Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study
Nature Medicine, Published online: 11 March 2026; doi:10.1038/s41591-026-04288-8
Author Correction: Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study
Clinical development of cancer vaccines
Nature Medicine, Published online: 11 March 2026; doi:10.1038/s41591-026-04241-9
This Review highlights insights from recent clinical trials and discusses critical factors for optimizing cancer vaccines, with a focus on proxies for vaccine efficacy, neoantigen selection, modular platforms and early intervention.
Gene conversion empowers natural selection in a clonal fish species
Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10180-9
Analysis of the asexually reproducing Amazon molly Poecilia formosa and its sexually reproducing progenitors Poecilia mexicana and Poecilia latipinna reveals that it maintains a divergent mutational landscape and has evaded functional mutational decay via gene conversion.
A mechanism to initiate emergency type 2 myelopoiesis
Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10256-6
Myelopoiesis in response to a parasitic worm infection and the mechanism selective to this form of parasite are revealed.
In vivo endosomal escape assay identifies mechanisms for efficient hepatic LNP delivery
Nature Biotechnology, Published online: 11 March 2026; doi:10.1038/s41587-026-03022-6
Endosomal escape of lipid nanoparticles is quantified and optimized in vivo.
Cereblon (CRBN) inhibits prostate cancer metastasis by negatively regulating 6-phosphogluconate dehydrogenase (6PGD)
Oncogene, Published online: 09 March 2026; doi:10.1038/s41388-026-03717-9
Cereblon (CRBN) inhibits prostate cancer metastasis by negatively regulating 6-phosphogluconate dehydrogenase (6PGD)