Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10446-2

Structural modifications in strain-engineered bilayer nickelate thin films

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10310-3

DNA damage burden and inadequate repair in CUX2+ cortical layer 2/3 excitatory neurons contributes to selective vulnerability in neuroinflammatory injury.

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10313-0

Findings suggest that neural crest fate bias predominantly emerges within the neural tube, and that only a minor subset of delaminated progenitors retain multipotency to generate both sensory and sympathetic derivatives.

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10299-9

N-desethyl-fluornitrazene is a µ-opioid receptor agonist derived from nitazenes that has supramaximal intrinsic efficacy that produces analgesia with minimal adverse effects in rodent models.

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10290-4

The transcription factor ATF4 is shown to regulate double-stranded DNA repair within vulnerable CUX2+ upper-layer 2/3 cortical neurons, enabling their survival during development.

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10203-5

A study of reproducibility in a stratified random sample of 600 papers published from 2009 to 2018 in 62 journals spanning the social and behavioural sciences finds higher reproducibility among more recent papers and papers from journals that require data sharing.

Nature, Published online: 01 April 2026; doi:10.1038/s41586-025-10078-y

A large-scale study on the replicability of claims from social and behavioural science journals reports that about half of the results replicate in the same patterns as the original study.

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10312-1

The rate of axon ensheathment varies within individual myelinating processes, resulting in chains of myelin sheaths connected by bridges consisting of thin cytoplasmic processes that provide flexibility for myelination of highly branched axons.

Nature, Published online: 01 April 2026; doi:10.1038/s41586-025-09844-9

When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10284-2

Megachelicerax cousteaui gen. et sp. nov. is a large soft-bodied arthropod from the middle Cambrian of Utah featuring massive three-segmented chelicerae, along with five pairs of pseudobiramous prosomal limbs with non-foliaceous exopodal rami, and plate-like lamellae-bearing opisthosomal appendages.

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10303-2

A fully automated methodology based on rubrics capturing a broad range of cognitive and intellectual demands is illustrated using LLMs and tasks, demonstrating a new way to evaluate the capabilities of AI systems and anticipate their performance.

Cell Death Discovery, Published online: 01 April 2026; doi:10.1038/s41420-026-03084-0

Brain metastases exhibit distinct spatial patterns of resident and infiltrating macrophages

Cell Death Discovery, Published online: 01 April 2026; doi:10.1038/s41420-026-03066-2

A unified therapeutic theory for treating cancer via master regulators of the universal apoptosis network

Nature Biotechnology, Published online: 31 March 2026; doi:10.1038/s41587-026-03068-6

Simultaneous profiling of adenylated and non-adenylated RNAs reveals regulatory programs across diverse cell types.

Nature, Published online: 31 March 2026; doi:10.1038/s41586-026-10335-8

Author Correction: Signatures of ambient pressure superconductivity in thin film La₃Ni₂O₇

Nature, Published online: 31 March 2026; doi:10.1038/s41586-026-10389-8

Author Correction: Phenome-wide analysis of copy number variants in 470,727 UK Biobank genomes

Nature, Published online: 31 March 2026; doi:10.1038/d41586-026-00987-x

Some researchers remain underwhelmed by NASA’s upcoming lunar fly-by.

Cell Death Discovery, Published online: 31 March 2026; doi:10.1038/s41420-026-03040-y

SNHG10 promotes tumorigenesis through the EGFR/AKT/ERK/mTOR and miR-150-5p/VEGF-A axis, along with gemcitabine resistance in pancreatic ductal adenocarcinoma

Nature Medicine, Published online: 31 March 2026; doi:10.1038/s41591-026-04315-8

Benralizumab (an anti-IL-5 receptor α antibody), compared to placebo, significantly reduced the risk of first flare in patients with hypereosinophilic syndrome.

Oncogene, Published online: 30 March 2026; doi:10.1038/s41388-026-03770-4

Editorial Expression of Concern: GRP78 regulates clusterin stability, retrotranslocation and mitochondrial localization under ER stress in prostate cancer