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Functional RNA splitting drove the evolutionary emergence of type V CRISPR-Cas systems from transposons
(Cell 188, 6283β6300.e1βe10; October 30, 2025)
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Genetically encoded fluorescent reporters to visualize Ξ±-synuclein pathology in live brain
The development of genetically encoded fluorescent reporters, along with their corresponding knock-in mouse lines for labeling Ξ±-Syn inclusions, enables diverse applications in studying the propagation and pathological effects of Ξ±-Syn inclusions in the live brain.
Gene regulatory landscape dissected by single-cell four-omics sequencing
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10322-z
Combining single-cell parallel profiling of genome conformation, histone modifications, chromatin accessibility and gene expression reveals dynamics and intranuclear spatial clustering of epigenome profiles, enabling sophisticated analysis of the regulatory landscape across cell types and tissues.