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Decipher-MR: a vision-language foundation model for 3D MRI representations
npj Digital Medicine, Published online: 04 April 2026; doi:10.1038/s41746-026-02596-4
Decipher-MR: a vision-language foundation model for 3D MRI representations
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Correction: The cytotoxicity of gomesin peptides is mediated by the glycosphingolipid pathway and lipid-cholesterol interactions
Cell Death Discovery, Published online: 02 April 2026; doi:10.1038/s41420-026-03009-x
Correction: The cytotoxicity of gomesin peptides is mediated by the glycosphingolipid pathway and lipid-cholesterol interactions
Deconstruction of a spino-brain–spinal cord circuit that drives chronic pain
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10296-y
In mice, a circuit between the spinal cord and various regions of the brain, centring on spinal-cord-projecting neurons in the rostral ventromedial medulla, has a key role in driving chronic pain.
General scales unlock AI evaluation with explanatory and predictive power
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10303-2
A fully automated methodology based on rubrics capturing a broad range of cognitive and intellectual demands is illustrated using LLMs and tasks, demonstrating a new way to evaluate the capabilities of AI systems and anticipate their performance.
Reproducibility and robustness of economics and political science research
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10251-x
Robustness checks and reproduction of analyses with existing and updated data based on 110 articles in economics and political science journals with data and code-sharing requirements found high levels of robustness and reproducibility and determined that robustness was not dependent on author characteristics or data availability.
Super-potent opioids could be safer-than-expected alternatives to conventional painkillers
Nature, Published online: 01 April 2026; doi:10.1038/d41586-026-00806-3
Modified nitazenes, opioids 1,000 times stronger than morphine, show remarkably few adverse effects in rodents, renewing the potential of these drugs for pain relief.
Moderate global warming does not rule out extreme global climate outcomes
Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10237-9
Extreme global climate outcomes may occur even under moderate 2 °C warming and may turn out to be more extreme than model-averaged projections at 3 °C or 4 °C warming.
Autophagy inhibition potentiates the antileukemic effect of FLT3 inhibitors and overcomes resistance in <i>FLT3</i>-ITD acute myeloid leukemia
Cell Death Discovery, Published online: 24 March 2026; doi:10.1038/s41420-026-03037-7
Autophagy inhibition potentiates the antileukemic effect of FLT3 inhibitors and overcomes resistance in FLT3-ITD acute myeloid leukemia
Human-specific features of the cerebellum and ZP2-regulated synapse development
Human-specific transcriptomic and regulatory features are present in the cerebellum, with ZP2 playing a key role in synapse regulation. ZP2 expression is induced by pontine mossy fibers, leading to decreased synaptic proteins and neuronal activity, which provides insights into the evolutionary development of the human cerebellum.
Author Correction: Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study
Nature Medicine, Published online: 11 March 2026; doi:10.1038/s41591-026-04288-8
Author Correction: Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study