npj Digital Medicine, Published online: 28 March 2026; doi:10.1038/s41746-026-02575-9

A multicenter randomized clinical trial of portable transcranial alternating current stimulation for major depressive disorder

Histidine scanning represents a broadly applicable technique for the identification of critical interaction sites within TCRs and other mechanosensory receptors to enhance receptor signaling strength and augment therapeutic efficacy via the catch bond mechanism.