Molecular basis for methylation-sensitive editing by Cas9

Nature - Issue - nature.com science feeds

By: Mitchell O. Roth · Yuerong Shu · Yu Zhao · Despoina Trasanidou · Renee D. Hoffman · Christian Südfeld · Eugenios Bouzetos · Nikolaos Trasanidis · Michael Zawrotny · Mary K. Gelasco · Megan L. Medina · Anuska Das · Jay Rai · Hemant N. Goswami · Bing Wang · John van der Oost · Hong Li

15 April 2026 at 08:00

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10384-z

ThermoCas9, a genome-editing enzyme that is sensitive to the DNA methylation status of the target locus, is characterized and shows promise for targeting hypomethylated DNA regions in cancer cells.

EBV strain interacts with host HLA to drive nasopharyngeal carcinoma risk

Nature - Issue - nature.com science feeds

By: Yanhong Chen · Jingtong Liang · Wanlin Zhang · Xinyu Zhang · Xinyi Zhang · Ching-Yuan Wang · Fei Yao · Shanshan Zhang · Xiang Zhou · Weimin Ye · Ruimei Feng · Yonglin Cai · Zhe Zhang · Mingfang Ji · Qian Cui · Xihong Lin · Jiesen Li · Jialei Xu · Qiuting Zhang · Qinyao Huang · Yingying Cheng · Yanran Luo · Xiaoping Ye · Qisheng Feng · Minzhong Tang · Mu-Sheng Zeng · Yi-Xin Zeng · Zhonghua Liu · Weiwei Zhai · Jianjun Liu · Miao Xu

15 April 2026 at 08:00

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10416-8

A genome-to-genome association study identifies host and viral risk factors that interact to drive nasopharyngeal carcinoma endemicity in southern China.

Transplantation of encapsulated mitochondria alleviates dysfunction in mitochondrial and Parkinson’s disease models

Cell

By: Shiwei Du · Qi Long · Yanshuang Zhou · Jiangqin Fu · Hao Wu · Liang Yang · Yaohang Xie · Yingzhe Ding · Maolei Zhang · Jingyi Guo · Mengfei Wang · Jiajun Lin · Mingli Hu · Jian Zhang · Deyang Yao · Wei Li · Feixiang Bao · Ge Xiang · Yi Wu · Yile Huang · Haozhao Liang · Rui Wang · Heying Li · Baodan Chen · Chong Li · Junwei Wang · Jiwei Zhang · Dajiang Qin · Jianwei Sun · Yun Zhu · Fei Sun · Wuming Wang · Gang Lu · Wai-Yee Chan · Hui Zhao · Chenli Liu · Xingguo Liu

18 March 2026 at 08:00

A mitochondrial transplantation approach rescues mitochondrial deficiency and prevents mitochondrial DNA depletion syndrome, Leigh syndrome, and Parkinson’s disease in cellular and mouse models.

Functional RNA splitting drove the evolutionary emergence of type V CRISPR-Cas systems from transposons

Cell

By: Shuai Jin · Zixu Zhu · Yunjia Li · Shouyue Zhang · Yijing Liu · Danyuan Li · Yuanqing Li · Yingfeng Luo · Zhiheng Cheng · Kevin Tianmeng Zhao · Qiang Gao · Guanglei Yang · Hongchao Li · Ronghong Liang · Rui Zhang · Jin-Long Qiu · Yong E. Zhang · Jun-Jie Gogo Liu · Caixia Gao

17 March 2026 at 08:00

(Cell 188, 6283–6300.e1–e10; October 30, 2025)

Restoring circadian rhythms in the hypothalamic paraventricular nucleus reverses aging biomarkers and extends lifespan in male mice

Cell

By: Haijiao Zhao · Meimei Liao · Ran Huo · Ting He · Hongni Tian · Zeqi Li · Chen Chen · Ziqing Yu · Juan Chai · Xiaocui Song · Ruichao Shao · Shuhua Ying · Wen Gao · Ling Liu · Di Sang · Qi Li · Haohong Li · Fengchao Wang · Dapeng Ju · Eric Erquan Zhang

4 March 2026 at 08:00

Enhancing circadian amplitude in mouse hypothalamic paraventricular nucleus neurons by 3′-deoxyadenosine treatment alleviates age-related pathologies and extends lifespan.