Nature Medicine, Published online: 26 May 2026; doi:10.1038/s41591-026-04401-x

Biobanks are introducing trusted research environments to enable secure data access, yet they can increase costs and complexity for biomedical researchers who use them. We discuss challenges and solutions and introduce the Python Phenofhy community tool for Our Future Health.

Nature Medicine, Published online: 26 May 2026; doi:10.1038/s41591-026-04376-9

In a multicenter phase 2 trial, the fibroblast growth factor receptor inhibitor rogaratinib showed encouraging clinical efficacy in patients with succinate dehydrogenase-deficient gastrointestinal stromal tumors, suggesting a potential new treatment option for this patient population and demonstrating that an epigenetic mechanism of oncogene activation can be successfully targeted with a tyrosine kinase inhibitor.

Cell Death Discovery, Published online: 26 May 2026; doi:10.1038/s41420-026-03151-6

Reprogramming temozolomide response in glioblastoma through regulated and immunogenic cell death modalities

Nature Cancer, Published online: 25 May 2026; doi:10.1038/s43018-026-01165-8

In this phase 2 trial, Perez et al. reported the safety of the vitamin D receptor agonist paricalcitol with gemcitabine and nab-paclitaxel in patients with metastatic pancreatic ductal adenocarcinoma and the pharmacodynamic effects of paricalcitol in fibroblasts and immune cells.

Nature Medicine, Published online: 22 May 2026; doi:10.1038/s41591-026-04416-4

At week 68, in patients who experienced poor weight loss following bariatric surgery, semaglutide was associated with 18.0% weight loss compared to 0.4% weight gain in patients receiving placebo.

Nature Medicine, Published online: 22 May 2026; doi:10.1038/s41591-026-04438-y

Will medical trainees who rely on AI fail to develop foundational independent clinical reasoning? This Perspective outlines a precautionary framework to preserve foundational competence while supporting safe and effective AI integration in medical training.

Nature, Published online: 21 May 2026; doi:10.1038/s41586-026-10656-8

De novo design of miniproteins targeting GPCRs

Oncogenesis, Published online: 21 May 2026; doi:10.1038/s41389-026-00628-y

Catestatin peptide impedes melanoma progression and drug resistance by reprogramming oncogenic signaling pathways

Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10464-0

Researchers designed two-component proteins forming quasisymmetric cages via geometric frustration, enabling tunable virus-like assemblies for cargo delivery, cellular uptake and studying intracellular diffusion and protein localization.

Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10297-x

A drawing-like task designed to study compositional generalization identifies a specific neural population in the ventral premotor cortex in primates that encodes action symbols.

Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10571-y

The buffer pool designed to compensate for unintended carbon losses from the largest forest climate mitigation programme in the United States is too small when considering the impact of future climate change scenarios.

Nature Cancer, Published online: 20 May 2026; doi:10.1038/s43018-026-01168-5

Castro-Dopico et al. report the design of reagents to bridge F-actin and Fcγ receptors, endowing a range of antigen-presenting cells with the ability to cross-present antigens from dead tumor cells and boosting antitumor immunity in preclinical models.

Nature Biotechnology, Published online: 20 May 2026; doi:10.1038/s41587-026-03123-2

Prime editing is improved with engineered RNA-stabilizing motifs.

Nature, Published online: 19 May 2026; doi:10.1038/s41586-026-10652-y

A multi-agent system for automating scientific discovery

Nature Cancer, Published online: 15 May 2026; doi:10.1038/s43018-026-01172-9

Jayaram et al. assessed the performance of the combination of circulating tumor DNA and serum prostate-specific antigen for dynamic monitoring of metastatic prostate cancer at first-line treatment in this prospective observational clinical trial.

Multiomics profiling of healthy individuals reveals differences across molecular layers and key pathways related to immune, metabolic, and microbiome-linked processes across ethnicities, while geographic relocation reshapes these networks and influences aging trajectories.

Oncogene, Published online: 11 May 2026; doi:10.1038/s41388-026-03821-w

Editorial Expression of Concern: Disruption of transforming growth factor-β signaling through β-spectrin ELF leads to hepatocellular cancer through cyclin D1 activation

Science, Ahead of Print.

An optogenetic model of accelerated intermittent theta burst stimulation reveals cell type-specific plasticity mechanisms and a key role for a fronto-insular circuit in driving the antidepressant effects of this treatment in humans.

Cancers evade RAS-targeting molecular glues through distinct alterations that converge on disrupting synthetic complex formation, exposing strategies for improved drug design and rational combination therapy.